Ignite Creation Date:
2024-05-05 @ 5:00 PM
Last Modification Date:
2024-10-26 @ 9:26 AM
Study NCT ID:
NCT00363571
Status:
UNKNOWN
Last Update Posted:
2006-08-15
First Post:
2006-08-14
Brief Title:
The Effect of Glyceryl Trinitate and Diamox on Cerebral Haemodynamics
Sponsor:
Danish Headache Center
Organization:
Danish Headache Center
Study Overview
Official Title:
The Effect of Glyceryl Trinitrate GTN and Diamox on Cerebral Haemodynamics Judged With the Help of 3-Tesla MRI
Status:
UNKNOWN
Status Verified Date:
2006-07
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
After infusion injection of Glyceryl trinitrate and Diamox it is wished to study the effect of drugs on the cerebral haemodynamics such as Cerebral blod flow and cerebral blod volume
Detailed Description:
Experimental headache model open a unike opportunity to study the pathophysiological mechanisms behind headache in general and migrane in particular Previous studies have used various techniques to study the cerebral haemodynamics as a basis for the headache pathophysiology We wish to use a 3-Tesa MRI so study the cerebral haemodynamics after application of various pharmacological substances
The most used experimental headache model is the glyceryl trinitrate model GTN Where infusion of the NO donor GTN induces headache and changes in the cerebral arteries On the other hand injection of Diamox Acetazolamide apparently causes increase of the cerebral blod flow with out dilation of the arteries We wish to study the precise effect of GTN and diamox on the cerebral haemodynamics such as Cerebral blod flow CBF and Cerebral blod volume CBV via a 3-Tesla MRI
The most used experimental headache model is the glyceryl trinitrate model GTN Where infusion of the NO donor GTN induces headache and changes in the cerebral arteries On the other hand injection of Diamox Acetazolamide apparently causes increase of the cerebral blod flow with out dilation of the arteries We wish to study the precise effect of GTN and diamox on the cerebral haemodynamics such as Cerebral blod flow CBF and Cerebral blod volume CBV via a 3-Tesla MRI
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None