Ignite Creation Date:
2024-05-06 @ 1:45 PM
Last Modification Date:
2024-10-26 @ 1:19 PM
Study NCT ID:
NCT04114396
Status:
UNKNOWN
Last Update Posted:
2020-11-03
First Post:
2019-03-14
Brief Title:
Poor Response to Monoclonal Therapy in Asthma
Sponsor:
University of Nottingham
Organization:
University of Nottingham
Study Overview
Official Title:
Investigating Poor Response to Monoclonal Therapy in Asthma
Status:
UNKNOWN
Status Verified Date:
2020-11
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PROCLAIM
Brief Summary:
Asthma affects 8 of the entire population 4-5 of asthma sufferers have severe asthma characterised by recurrent exacerbations worsening of symptoms leading to the person having a bout of corticosteroids andor antibiotics significant symptoms and lack of response to the most widely used therapy corticosteroids
There is now new types of treatments antibody drugs which are licensed to manage severe asthma such as Anti-IL5 There is evidence Anti-IL5 and other similar antibody drugs are effective at reducing asthma exacerbations and reduce the need for oral corticosteroids for those that have severe asthma
However some patients respond poorly to Anti-IL5 and the investigators would like to find out why this happens It is hoped that the investigators can identify the mechanism of poor treatment response to Anti-IL5 It is also hoped that the investigators can understand why symptoms worsen to the point of requiring antibiotics andor steroids also known as an exacerbation for those prescribed Anti-IL5
There is now new types of treatments antibody drugs which are licensed to manage severe asthma such as Anti-IL5 There is evidence Anti-IL5 and other similar antibody drugs are effective at reducing asthma exacerbations and reduce the need for oral corticosteroids for those that have severe asthma
However some patients respond poorly to Anti-IL5 and the investigators would like to find out why this happens It is hoped that the investigators can identify the mechanism of poor treatment response to Anti-IL5 It is also hoped that the investigators can understand why symptoms worsen to the point of requiring antibiotics andor steroids also known as an exacerbation for those prescribed Anti-IL5
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None