Ignite Creation Date:
2024-05-06 @ 1:42 PM
Last Modification Date:
2024-10-26 @ 1:18 PM
Study NCT ID:
NCT04092244
Status:
UNKNOWN
Last Update Posted:
2020-05-28
First Post:
2019-09-15
Brief Title:
Role of CTHRC1 in Diagnosis of Rheumatoid Arthritis
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
CTHRC1 as a New Biomarker in Diagnosis of Rheumatoid Arthritis and Its Role in Seronegative Patients
Status:
UNKNOWN
Status Verified Date:
2020-05
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
to detect the role of CTHRC1 biomarker in diagnosis of rheumatoid arthritis and To correlate other well-established rheumatoid arthritis markers RF anti-ccp and CTHRC1 level to see if CTHRC1 can act as a dependent or independent serum marker in prediction of RA status
Detailed Description:
Rheumatoid arthritis RA is a chronic progressive autoimmune disease of synovial joints Disease progression is characterized by periods of high disease activity involving both a systemic immune response and tissue-specific inflammatory events that may lead to joint and bone destruction and subsequent disability
Rheumatoid arthritis is a multifactorial disease with significant contribution from genetic and non-genetic factors that together account for complex disease pathology
Diagnosis of RA is based mainly on detection of high titers of rheumatoid factor RF and of antibodies against cyclic citrullinated peptide anti-CCP or against citrullinated protein ACPA
The major RF species could be detected only in 60-70 of RA patients patients with high levels of RF have higher disease activity with greater disabilities
The problem is that RF is not a specific marker for RA and is often absent in early stages of the disease on the other hand ACPA and CCP auto antibodies provide high specificity but moderate sensitivity adding to that CRP and ESR are general indicators of inflammation and are not specific for RA
Collagen triple helix repeat containing 1 protein CTHRC1 is expressed in a number of embryonic and neonate tissues including developing cartilage and bone It is a secreted modulator of Wnt signaling which is a key regulator of joint remodeling and promotes cell proliferation and migration
Immunohistochemical analysis of various human primary cancers and metastases has revealed that CTHRC1 expression is actually limited to the stromal cells of solid tumors
The expression of CTHRC1 encoding gene was found to be strongly associated with the severity of murine collagen antibody-induced arthritis
Arthritic pannus is a multicellular vascularized tissue composed of cells of both mesenchymal and hematopoietic origin including synovial fibroblasts osteoclasts endothelial cells dendritic cells monocytesmacrophages as well as T and B cells that contribute to the development and progression of joint and cartilage erosion through secretion of pro-inflammatory cytokines and tissue-degrading proteases Fibroblast-like synoviocytes FLS particularly the invasive and migratory cadherin-11-positive subtype are major components of synovial pannus tissue and are considered active drivers in the pathogenesis of RA
The expression of CTHRC1 in pannus and its role in the function of FLS relevant to cartilage damage in RA make it of great value if used as a blood-based biomarker for improved diagnosis of rheumatoid arthritis patients
Rheumatoid arthritis is a multifactorial disease with significant contribution from genetic and non-genetic factors that together account for complex disease pathology
Diagnosis of RA is based mainly on detection of high titers of rheumatoid factor RF and of antibodies against cyclic citrullinated peptide anti-CCP or against citrullinated protein ACPA
The major RF species could be detected only in 60-70 of RA patients patients with high levels of RF have higher disease activity with greater disabilities
The problem is that RF is not a specific marker for RA and is often absent in early stages of the disease on the other hand ACPA and CCP auto antibodies provide high specificity but moderate sensitivity adding to that CRP and ESR are general indicators of inflammation and are not specific for RA
Collagen triple helix repeat containing 1 protein CTHRC1 is expressed in a number of embryonic and neonate tissues including developing cartilage and bone It is a secreted modulator of Wnt signaling which is a key regulator of joint remodeling and promotes cell proliferation and migration
Immunohistochemical analysis of various human primary cancers and metastases has revealed that CTHRC1 expression is actually limited to the stromal cells of solid tumors
The expression of CTHRC1 encoding gene was found to be strongly associated with the severity of murine collagen antibody-induced arthritis
Arthritic pannus is a multicellular vascularized tissue composed of cells of both mesenchymal and hematopoietic origin including synovial fibroblasts osteoclasts endothelial cells dendritic cells monocytesmacrophages as well as T and B cells that contribute to the development and progression of joint and cartilage erosion through secretion of pro-inflammatory cytokines and tissue-degrading proteases Fibroblast-like synoviocytes FLS particularly the invasive and migratory cadherin-11-positive subtype are major components of synovial pannus tissue and are considered active drivers in the pathogenesis of RA
The expression of CTHRC1 in pannus and its role in the function of FLS relevant to cartilage damage in RA make it of great value if used as a blood-based biomarker for improved diagnosis of rheumatoid arthritis patients
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None