Ignite Creation Date:
2024-05-05 @ 4:59 PM
Last Modification Date:
2024-10-26 @ 9:27 AM
Study NCT ID:
NCT00368862
Status:
COMPLETED
Last Update Posted:
2006-08-29
First Post:
2006-08-28
Brief Title:
Efficacy Study of Memantine Hydrochloride and Escitalopram for the Treatment of Co-Morbid Depression and Alcoholism
Sponsor:
Finnish Institute for Health and Welfare
Organization:
Finnish Institute for Health and Welfare
Study Overview
Official Title:
Phase Four Double-Blind Randomized Comparative Study on Thestudy on the Efficacy of Memantine Hydrochloride and Escitalopram for the Treatment of Co-Morbid Depression and Alcoholism
Status:
COMPLETED
Status Verified Date:
2006-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of the present study was to examine the influence of memantine a noncompetitive NMDA receptor blocker in depression co-morbid with long term alcohol heavy use comparing to SSRI-inhibitor escitalopram Second goal is to compare their influence to cognitive tasks and the third goal is to follow up alcohol-use with these two medicines
Detailed Description:
Context Depression is common clinical problem among alcoholics and its treatment has no standard and is controversy Glutamate NMDA-receptors may mediate the effects of long term alcohol related depression and thus the NMDA-receptor modulator memantine could have effects on it
Objectives The preliminary aim of this study was to identify possible new treatment for depression of alcoholics and compare the efficacy of escitalopram and memantine in co-morbid depression of alcoholism
Design and setting Double-blind randomized naturalistic study 26-week trial on alcohol dependent outpatients
Participants Eighty alcohol dependent depressive adults
Intervention Subjects were randomized 11 to receive memantine or escitalopram 20 mg per day During the study the patient received routine psychosocial treatment at A-Clinic No concomitant intervention on alcohol consumption and no imposed treatment goals The patients were met weekly in first month then after 3 and 6 months
Objectives The preliminary aim of this study was to identify possible new treatment for depression of alcoholics and compare the efficacy of escitalopram and memantine in co-morbid depression of alcoholism
Design and setting Double-blind randomized naturalistic study 26-week trial on alcohol dependent outpatients
Participants Eighty alcohol dependent depressive adults
Intervention Subjects were randomized 11 to receive memantine or escitalopram 20 mg per day During the study the patient received routine psychosocial treatment at A-Clinic No concomitant intervention on alcohol consumption and no imposed treatment goals The patients were met weekly in first month then after 3 and 6 months
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None