Ignite Creation Date:
2024-05-06 @ 1:39 PM
Last Modification Date:
2024-10-26 @ 1:17 PM
Study NCT ID:
NCT04081506
Status:
WITHDRAWN
Last Update Posted:
2020-11-04
First Post:
2019-09-04
Brief Title:
Targeting the Optimal Mean Arterial Pressure in Hypoxic Ischemic Brain Injury After Cardiac Arrest
Sponsor:
University of British Columbia
Organization:
University of British Columbia
Study Overview
Official Title:
Targeting the Optimal Mean Arterial Pressure in Hypoxic Ischemic Brain Injury After Cardiac Arrest
Status:
WITHDRAWN
Status Verified Date:
2020-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
COVID-19 pandemic
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
CAMPING
Brief Summary:
Hypoxic ischemic brain injury HIBI is the ensuing brain injury after cardiac arrest and is the primary cause of adverse outcome HIBI is caused by low oxygen delivery to the brain The patients blood pressure is primary determinant of oxygen delivery to the brain International guidelines recommend maintaining uniform blood pressure targets in all patients however this one size fits all approach fails to account for individual baseline differences between patients blood pressures and extent of underlying disease Recently autoregulation monitoring a novel brain monitoring technique has emerged as a viable tool to identify patient specific blood pressures after brain injury This personalized medicine approach of targeting patient specific blood pressure MAPopt is associated with improved outcome in traumatic brain injury It has not been evaluated in HIBI after cardiac arrest
Recently I completed a first-in-human study demonstrating the ability to identify MAPopt in HIBI patients using neuromonitoring microcatheters inserted into the brain tissue The proposed study in this grant is to take the next step and investigate the changes in key brain physiologic variables brain blood flow and oxygenation before and after therapeutically targeting MAPopt in HIBI patients This interventional study will serve as the basis to embark on a pilot randomized control trial of MAPopt targeted therapy versus standard of care in HIBI patients after cardiac arrest
Recently I completed a first-in-human study demonstrating the ability to identify MAPopt in HIBI patients using neuromonitoring microcatheters inserted into the brain tissue The proposed study in this grant is to take the next step and investigate the changes in key brain physiologic variables brain blood flow and oxygenation before and after therapeutically targeting MAPopt in HIBI patients This interventional study will serve as the basis to embark on a pilot randomized control trial of MAPopt targeted therapy versus standard of care in HIBI patients after cardiac arrest
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None