Ignite Creation Date:
2024-05-05 @ 4:59 PM
Last Modification Date:
2024-10-26 @ 9:27 AM
Study NCT ID:
NCT00368004
Status:
TERMINATED
Last Update Posted:
2019-12-17
First Post:
2006-08-23
Brief Title:
Family Studies of Uveal Coloboma
Sponsor:
National Eye Institute NEI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Family Studies of Uveal Coloboma
Status:
TERMINATED
Status Verified Date:
2013-04-15
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will identify the genes responsible for uveal coloboma an abnormal development of the eye caused by incomplete closure of a normally-occurring gap in the eye the optic fissure after the fifth week of life in a human embryo There have been studies of families in which more than one person has been affected by this disorder Coloboma occurs in about 1 of 10000 live births and may cause significant vision loss Researchers seek a better understanding of the genes responsible for this disorder
Adults and children who have more than one member of the family with uveal coloboma may be eligible for this study Patients will undergo a detailed medical history and eye examination appropriate for their age The pupils will be dilated through the use of eye drops Dilation will continue for 4 to 6 hours and wearing of sunglasses can reduce temporary glare that many patients may experience in brightly lit areas In addition pictures will be taken of the front or back of the eye a procedure that also involves dilation of the pupils Patients who have coloboma will undergo a complete physical examination Blood samples will be collected with a total of about 2 tablespoons from patients ages 10 and older and about 1 teaspoon for each 5 pounds of body weight for younger patients Also patients with coloboma may be asked to undergo X-rays ultrasound or other tests that are medically indicated
To have enough DNA to study the researchers may create a cell line to grow more DNA Laboratory samples will be coded so that there is no identifying information about participants in this study No other testing or research will be done on blood samples collected unless patients give permission The researchers will not provide information about patients health to other people without your express permission
Adults and children who have more than one member of the family with uveal coloboma may be eligible for this study Patients will undergo a detailed medical history and eye examination appropriate for their age The pupils will be dilated through the use of eye drops Dilation will continue for 4 to 6 hours and wearing of sunglasses can reduce temporary glare that many patients may experience in brightly lit areas In addition pictures will be taken of the front or back of the eye a procedure that also involves dilation of the pupils Patients who have coloboma will undergo a complete physical examination Blood samples will be collected with a total of about 2 tablespoons from patients ages 10 and older and about 1 teaspoon for each 5 pounds of body weight for younger patients Also patients with coloboma may be asked to undergo X-rays ultrasound or other tests that are medically indicated
To have enough DNA to study the researchers may create a cell line to grow more DNA Laboratory samples will be coded so that there is no identifying information about participants in this study No other testing or research will be done on blood samples collected unless patients give permission The researchers will not provide information about patients health to other people without your express permission
Detailed Description:
Objective To describe phenotypes and find genes causing a developmental and potentially blinding eye condition uveal coloboma
Study population Families where more than one family member has uveal coloboma Both affected and genetically informative unaffected members of the family will be recruited
Design Observational study
Outcome measures Clinical examination genetic mapping and mutation identification
Study population Families where more than one family member has uveal coloboma Both affected and genetically informative unaffected members of the family will be recruited
Design Observational study
Outcome measures Clinical examination genetic mapping and mutation identification
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 06-EI-0230 | None | None | None |