Ignite Creation Date:
2024-05-05 @ 11:08 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005421
Status:
COMPLETED
Last Update Posted:
2016-03-16
First Post:
2000-05-25
Brief Title:
Blood Pressure Tracking--Childhood to Young Adulthood
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2005-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To extend analyses of blood pressure BP tracking to a period that spanned childhood and young adulthood Data were used from the same cohort of 339 children who had been followed for nine to twelve years in a previous study
Detailed Description:
BACKGROUND
Blood pressure measurements in childhood and young adulthood are less predictive of future levels than those taken in middle age In part this may be due to the fact that within-person variability appears to make up a larger proportion of total variability in childhood than adulthood Previous work on an NHLBI supported grant indicated that repeated blood pressure measurements and visits led to higher childhood tracking correlations over a period of three years
DESIGN NARRATIVE
Follow-up data were used as well as multiple visits which reduced the large within-person variability of blood pressure measurements and improved the tracking correlations In addition true or corrected tracking correlations were provided by eliminating the effects of random measurement error The effects were examined of time-varying covariates on both the observed and true tracking correlations Besides computing tracking correlations predictive values were computed for young adult blood pressure given childhood levels This was the probability that a young adults true blood pressure was above a specific cutpoint conditional on childhood blood pressure These values were validated using data from the Fels Longitudinal Study which included serial blood pressure measurements over the age range in the study The prediction models were also derived including terms for covariates such as age sex height and weight From these models nomograms were constructed which were useful to physicians for prognostic purposes Thus because of the unique multiple-visit approach used in these data the effect of random measurement error was eliminated These methodologic improvements strengthened the usefulness of blood pressure screening in childhood to detect those at high risk of developing hypertension
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Blood pressure measurements in childhood and young adulthood are less predictive of future levels than those taken in middle age In part this may be due to the fact that within-person variability appears to make up a larger proportion of total variability in childhood than adulthood Previous work on an NHLBI supported grant indicated that repeated blood pressure measurements and visits led to higher childhood tracking correlations over a period of three years
DESIGN NARRATIVE
Follow-up data were used as well as multiple visits which reduced the large within-person variability of blood pressure measurements and improved the tracking correlations In addition true or corrected tracking correlations were provided by eliminating the effects of random measurement error The effects were examined of time-varying covariates on both the observed and true tracking correlations Besides computing tracking correlations predictive values were computed for young adult blood pressure given childhood levels This was the probability that a young adults true blood pressure was above a specific cutpoint conditional on childhood blood pressure These values were validated using data from the Fels Longitudinal Study which included serial blood pressure measurements over the age range in the study The prediction models were also derived including terms for covariates such as age sex height and weight From these models nomograms were constructed which were useful to physicians for prognostic purposes Thus because of the unique multiple-visit approach used in these data the effect of random measurement error was eliminated These methodologic improvements strengthened the usefulness of blood pressure screening in childhood to detect those at high risk of developing hypertension
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R03HL048289 | NIH | None | httpsreporternihgovquickSearchR03HL048289 |