Ignite Creation Date:
2024-05-05 @ 4:58 PM
Last Modification Date:
2024-10-26 @ 9:26 AM
Study NCT ID:
NCT00356174
Status:
COMPLETED
Last Update Posted:
2016-09-28
First Post:
2006-07-21
Brief Title:
An Observational Study of Childhood Food Allergy
Sponsor:
National Institute of Allergy and Infectious Diseases NIAID
Organization:
National Institute of Allergy and Infectious Diseases NIAID
Study Overview
Official Title:
A Prospective Cohort Study of Immune Mechanisms Genetic Factors and Clinical and Environmental Characteristics Associated With the Occurrence and Clinical Outcome of Food Allergy CoFAR2
Status:
COMPLETED
Status Verified Date:
2016-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to observe the natural course of food allergy including both the development of peanut allergy in infants at high risk for developing this allergy and the resolution of both egg and cows milk allergy
Detailed Description:
This observational study will investigate the developmental immunology of peanut egg and milk allergy in a cohort of milk- or egg-allergic children who are at risk for peanut allergy This strategy will help to delineate compare and contrast biological markers and immunologic changes associated with the development of peanut allergy and loss of egg and milk allergy while simultaneously evaluating important clinical and environmental influences likely to account for the recent rise in the prevalence of these allergies The hallmark of food-allergic disease is the production of food-specific Immunoglobulin E IgE antibodies that represent an end result of a T helper 2 Th2 influenced immune response Currently there is only a limited understanding of the mechanisms involved in the developmental course of food allergies To effectively prevent or reverse the progression of food allergy immune interventions will be needed Furthermore it is likely that successful strategies will need to be directed to those persons at identifiable risk eg who have biomarkers associated with development of peanut allergy
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None