Ignite Creation Date:
2024-05-06 @ 1:35 PM
Last Modification Date:
2024-10-26 @ 1:16 PM
Study NCT ID:
NCT04061499
Status:
WITHDRAWN
Last Update Posted:
2021-05-04
First Post:
2019-08-14
Brief Title:
Ultrasound and CT to Measure Muscle in Hip OA
Sponsor:
University of Maryland Baltimore
Organization:
University of Maryland Baltimore
Study Overview
Official Title:
A Combination of Ultrasound and CT for Investigation of Muscle and Functional Changes in Hip OA Across the Disease Spectrum
Status:
WITHDRAWN
Status Verified Date:
2021-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
COVID-19
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will examine alterations in muscle in individuals with hip osteoarthritis compared to individuals without hip arthritis All individuals will receive imaging of their hip and low back muscles in order to compare differences between groups The investigators hypothesize that there will be differences between groups and that these differences will be related to strength functional and balance impairments which will also be measured in all individuals
Detailed Description:
Hip osteoarthritis OA is one of the most common causes of disability in older adults with pain stiffness and weakness the most frequently reported symptoms Weakness is a major concern as decreased lower extremity strength is a contributor to balance and other mobility limitations that increase fall risk in the aging population Weakness in the primary hip muscles in particular have been shown to contribute to gait variability and altered mechanics of stepping when recovering from a balance perturbation Contributing factors for these strength deficits are multifactorial and may include decreased muscle masssize changes in muscle composition andor a decreased ability to activate the muscle Intramuscular fat infiltration IMAT has been reported in several conditions affecting older adults and has been shown to be more modifiable at lower levels suggesting that earlier detection and intervention may be important CT and MRI are both commonly used to measure these relevant muscle properties but ultrasound imaging may be valid alternative and has the advantage of being more accessible to clinicians in many settings The investigators hypothesize that cross-sectional area CSA and IMAT of the hip and lumbar musculature will be significantly altered in individuals with hip OA affected limb compared to that seen in similar-aged control participants and that larger differences in CSA and IMAT will be positively correlated with OA severity increased impairment pain and disability
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None