Ignite Creation Date:
2024-05-05 @ 11:08 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001527
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
1999-11-03
Brief Title:
Role of Endothelin in the Regulation of Vascular Tone in Patients With Essential Hypertension
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Role of Endothelin in the Regulation of Vascular Tone in Patients With Essential Hypertension
Status:
COMPLETED
Status Verified Date:
1999-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Endothelin-1 ET-1 is a powerful vasoconstricting peptide produced predominantly by vascular endothelial cells that exerts its effect through the interaction with specific receptors ETA and ETB on the underlying smooth muscle cells Previous studies in normal subjects have demonstrated an increase in forearm blood flow after ET-1 antagonism suggesting a physiologic role of ET-1 in the regulation of basal vascular tone However whether ET-1-mediated tone is increased in hypertensive patients is unknown
The main purpose of this study will be to compare the forearm vascular responses to local infusion of ET-1 receptor antagonists between normotensive and hypertensive subjects in order to assess whether ET-1-mediated basal tone is increased in patients with hypertension In addition we propose to study the vascular responses to local ET-1 infusion to determine whether vascular smooth muscle sensitivity to this peptide is increased in hypertensive vessels We will use both an ETA receptor antagonist BQ-123 and an ETB receptor antagonist BQ-788 in order to evaluate the relative contribution of the two receptor subtypes to the regulation of vascular tone
All drugs will be infused into the brachial artery and the responses of the forearm vasculature will be measured by means of strain gauge plethysmography Because of the relative long-lasting effect of most of the substances to be infused the study will be performed on two separate occasions
The main purpose of this study will be to compare the forearm vascular responses to local infusion of ET-1 receptor antagonists between normotensive and hypertensive subjects in order to assess whether ET-1-mediated basal tone is increased in patients with hypertension In addition we propose to study the vascular responses to local ET-1 infusion to determine whether vascular smooth muscle sensitivity to this peptide is increased in hypertensive vessels We will use both an ETA receptor antagonist BQ-123 and an ETB receptor antagonist BQ-788 in order to evaluate the relative contribution of the two receptor subtypes to the regulation of vascular tone
All drugs will be infused into the brachial artery and the responses of the forearm vasculature will be measured by means of strain gauge plethysmography Because of the relative long-lasting effect of most of the substances to be infused the study will be performed on two separate occasions
Detailed Description:
Endothelin-1 ET-1 is a powerful vasoconstricting peptide produced predominantly by vascular endothelial cells that exerts its effect through the interaction with specific receptors ETA and ETB on the underlying smooth muscle cells Previous studies in normal subjects have demonstrated an increase in forearm blood flow after ET-1 antagonism suggesting a physiologic role of ET-1 in the regulation of basal vascular tone However whether ET-1-mediated tone is increased in hypertensive patients is unknown
The main purpose of this study will be to compare the forearm vascular responses to local infusion of ET-1 receptor antagonists between normotensive and hypertensive subjects in order to assess whether ET-1-mediated basal tone is increased in patients with hypertension In addition we propose to study the vascular responses to local ET-1 infusion to determine whether vascular smooth muscle sensitivity to this peptide is increased in hypertensive vessels We will use both an ETA receptor antagonist BQ-123 and an ETB receptor antagonist BQ-788 in order to evaluate the relative contribution of the two receptor subtypes to the regulation of vascular tone
All drugs will be infused into the brachial artery and the responses of the forearm vasculature will be measured by means of strain gauge plethysmography Because of the relative long-lasting effect of most of the substances to be infused the study will be performed on two separate occasions
The main purpose of this study will be to compare the forearm vascular responses to local infusion of ET-1 receptor antagonists between normotensive and hypertensive subjects in order to assess whether ET-1-mediated basal tone is increased in patients with hypertension In addition we propose to study the vascular responses to local ET-1 infusion to determine whether vascular smooth muscle sensitivity to this peptide is increased in hypertensive vessels We will use both an ETA receptor antagonist BQ-123 and an ETB receptor antagonist BQ-788 in order to evaluate the relative contribution of the two receptor subtypes to the regulation of vascular tone
All drugs will be infused into the brachial artery and the responses of the forearm vasculature will be measured by means of strain gauge plethysmography Because of the relative long-lasting effect of most of the substances to be infused the study will be performed on two separate occasions
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 96-H-0016 | None | None | None |