Ignite Creation Date:
2024-05-05 @ 4:58 PM
Last Modification Date:
2024-10-26 @ 9:26 AM
Study NCT ID:
NCT00359307
Status:
COMPLETED
Last Update Posted:
2019-12-17
First Post:
2006-08-01
Brief Title:
Genetic Factors in Atherosclerosis
Sponsor:
National Institute of Allergy and Infectious Diseases NIAID
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Chemokine System Polymorphisms and Risk of Atherosclerosis CAD
Status:
COMPLETED
Status Verified Date:
2013-03-21
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to identify genes associated with certain risk factors for atherosclerosis hardening of the arteries and its consequences such as development of coronary artery disease heart attack other blood vessel disease and stroke
People enrolled in the Framingham Heart Study in Framingham Massachusetts are eligible to participate in this study They will undergo a medical history including review of their medical records and a family history evaluation of memory and mood breathing test and electrocardiogram EKG blood and urine tests including blood sample collection for DNA genetic testing evaluation of gait walking balance and hand grip strength and hearing test They will also fill out questionnaires on their eating habits and general health
Any patients who may suffer a stroke during the study will be examined during their hospitalization and at 3 6 12 and 24 months after the stroke This examination includes a neurological evaluation assessment of ability to perform daily living tasks and possibly magnetic resonance imaging MRI of the brain a test that uses a strong magnetic field and radio waves to produce pictures of the brain
People enrolled in the Framingham Heart Study in Framingham Massachusetts are eligible to participate in this study They will undergo a medical history including review of their medical records and a family history evaluation of memory and mood breathing test and electrocardiogram EKG blood and urine tests including blood sample collection for DNA genetic testing evaluation of gait walking balance and hand grip strength and hearing test They will also fill out questionnaires on their eating habits and general health
Any patients who may suffer a stroke during the study will be examined during their hospitalization and at 3 6 12 and 24 months after the stroke This examination includes a neurological evaluation assessment of ability to perform daily living tasks and possibly magnetic resonance imaging MRI of the brain a test that uses a strong magnetic field and radio waves to produce pictures of the brain
Detailed Description:
We are studying the relationship between genetic variants of the human immune system and atherosclerosis through a collaboration with the Framingham Heart Study Since atherosclerosis is a disease of chronic inflammation of the arterial vessel wall genetic variants in molecules that are responsible for the migration of leukocytes are likely to explain some of the genetic diversity in the rate of heart disease and strokes Therefore we are conducting a molecular epidemiology study of the genetics of atherosclerosis using materials and clinical data already collected by the Framingham Heart Study The Heart Study is a prospective epidemiological study of the natural history of heart disease and stroke that has involved individuals residing in Framingham Massachusetts since the 1950s We will compare risks of individuals with particular genotypes for developing atherosclerosis and its sequelae coronary artery disease heart attack peripheral vascular disease and stroke If correlations of genotype with risk of atherosclerosis can be found then this will facilitate new treatments of this disease based on interference with particular components of the human immune system
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 00-I-0143 | None | None | None |