Ignite Creation Date:
2024-05-05 @ 4:58 PM
Last Modification Date:
2024-10-26 @ 9:26 AM
Study NCT ID:
NCT00357695
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
2006-07-26
Brief Title:
Role of the Brain in Processing Visually Presented Objects
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Role of the Parieto-Frontal Network in Automatic Processing of Visually Presented Objects
Status:
COMPLETED
Status Verified Date:
2008-10-28
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will examine the parts of the brain that use visual information to perform movements Patients with certain brain lesions tend to have difficulty in processing visually presented objects This study will look at the brain mechanisms underlying the visuo-motor integration
Healthy normal volunteers between 20 and 60 years of age are eligible for this study People who have had a severe head injury with loss of consciousness or any other mental or neurological disorder diagnosed by a doctor may not participate Candidates will be screened with a medical history a physical examination focusing on finger movements and a questionnaire
Participants brain activity will be recorded using two techniques - magnetoencephalographyMEG and magnetic resonance imaging MRI - while they watch pictures of various objects flashed on a screen MEG is a procedure to record magnetic field changes produced by brain activity During the recording the subject sits comfortably in an armchair in a dimly lit room and watches pictures presented on a screen About 50 pictures are shown per session There are about five sessions separated by 3-minute breaks Functional MRI involves taking pictures of the brain using MRI while the subject performs a task MRI uses a strong magnetic field and radio waves to obtain images of body organs and tissues The MRI scanner is a metal cylinder surrounded by a magnetic field The subject lies still on a table that can slide in and out of the scanner During the scan he or she looks at pictures in six test blocks of 1 minute each with 30-second breaks between blocks
Healthy normal volunteers between 20 and 60 years of age are eligible for this study People who have had a severe head injury with loss of consciousness or any other mental or neurological disorder diagnosed by a doctor may not participate Candidates will be screened with a medical history a physical examination focusing on finger movements and a questionnaire
Participants brain activity will be recorded using two techniques - magnetoencephalographyMEG and magnetic resonance imaging MRI - while they watch pictures of various objects flashed on a screen MEG is a procedure to record magnetic field changes produced by brain activity During the recording the subject sits comfortably in an armchair in a dimly lit room and watches pictures presented on a screen About 50 pictures are shown per session There are about five sessions separated by 3-minute breaks Functional MRI involves taking pictures of the brain using MRI while the subject performs a task MRI uses a strong magnetic field and radio waves to obtain images of body organs and tissues The MRI scanner is a metal cylinder surrounded by a magnetic field The subject lies still on a table that can slide in and out of the scanner During the scan he or she looks at pictures in six test blocks of 1 minute each with 30-second breaks between blocks
Detailed Description:
Objectives Patients with frontal lobe lesions tend to grasp visually presented objects automatically and forcefully forced grasping Grasping of a milder form is seen in infants and the aged population These facts suggest the presence of an inherent mechanism for suppressing the automatic tendency toward grasping in the healthy adult brain Previous studies suggest that the parieto-frontal network especially the lateral premotor cortex play a role in the cognition of graspable objects and execution of reachinggrasping Although the task of reachinggrasping in human beings has been studied mainly by neuroimaging techniques its cognitive and executive aspects have not been clearly distinguished Therefore this project aims to elucidate the mechanisms underlying automatic grasping in humans focusing on the perceptivecognitive aspect of the reachinggrasping movements
Study population and design Pictures of graspable objects and non-graspable objects are visually presented to 45 healthy adult volunteers Since this study aims to clarify the mechanism of the human brain for automatically recognizing graspable objects part of this study will require no response task Additionally in order to assess how the automatic functions compare to overt mechanisms an extra testing session will explore making overt judgments of the pictures
Outcome measures The brain activations are investigated by event-related magnetic fields which have high temporal resolution and by event-related functional magnetic resonance imaging fMRI which has relatively high spatial resolution It is expected that the lateral premotor cortex in addition to the parietal cortex is activated by the visual presentation of graspable objects at a shorter latency and more strongly as compared with non-graspable objects even without any actual motor tasks to follow Additionally overt grasping of graspable objects will involve similar areas
Study population and design Pictures of graspable objects and non-graspable objects are visually presented to 45 healthy adult volunteers Since this study aims to clarify the mechanism of the human brain for automatically recognizing graspable objects part of this study will require no response task Additionally in order to assess how the automatic functions compare to overt mechanisms an extra testing session will explore making overt judgments of the pictures
Outcome measures The brain activations are investigated by event-related magnetic fields which have high temporal resolution and by event-related functional magnetic resonance imaging fMRI which has relatively high spatial resolution It is expected that the lateral premotor cortex in addition to the parietal cortex is activated by the visual presentation of graspable objects at a shorter latency and more strongly as compared with non-graspable objects even without any actual motor tasks to follow Additionally overt grasping of graspable objects will involve similar areas
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 04-N-0047 | None | None | None |