Ignite Creation Date:
2024-05-05 @ 4:58 PM
Last Modification Date:
2024-10-26 @ 9:26 AM
Study NCT ID:
NCT00356083
Status:
COMPLETED
Last Update Posted:
2016-07-29
First Post:
2006-07-24
Brief Title:
Opioid Rotation From Morphine to Methadone in Treatment of Non-malignant Pain
Sponsor:
Norwegian University of Science and Technology
Organization:
Norwegian University of Science and Technology
Study Overview
Official Title:
Opioid Switching From Oral Slow Release Morphine to Oral Methadone May Improve Pain Control in Chronic Non-malignant Pain a Nine-month Follow-up Study
Status:
COMPLETED
Status Verified Date:
2016-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Patients with non-malignant pain are switched from morphine to methadone with a nine-months follow-up
Detailed Description:
Twelve patients with poor pain control or unacceptable side effects during treatment with morphine were switched to methadone and followed for nine months in this open prospective study Primary outcomes were patient preference for opioid and pain control while physical cognitive and role functioning were secondary outcomes The morphine dose was decreased by 13 daily and was replaced with an equianalgesic dose of methadone over a three-day period During switching and a one-week dose titration period patients were given additional methadone if required During dose titration one patient experienced sedation requiring naloxone Four patients were switched back to morphine due to poor pain control drowsiness or sweating Seven patients preferred long-term nine months treatment with methadone and reported reduced pain and improved functioning while cognition was not improved This study brings novel information on the long-term consequences for pain control health-related quality of life and cognitive functioning with a switch from morphine to methadone in the treatment of chronic non-malignant pain
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None