Ignite Creation Date:
2024-05-06 @ 1:30 PM
Last Modification Date:
2024-10-26 @ 1:15 PM
Study NCT ID:
NCT04045808
Status:
COMPLETED
Last Update Posted:
2019-08-06
First Post:
2019-08-02
Brief Title:
Relationship of Oral Status to Coronary Artery Disease
Sponsor:
Baskent University
Organization:
Baskent University
Study Overview
Official Title:
Associate Professor
Status:
COMPLETED
Status Verified Date:
2019-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
We hypothesized that periodontal disease and edentulism could be a risk for CAD and there might be a relationship between the oral status and the number of main coronary vessels with 50 stenosis Therefore primary goal of this study is to investigate the connection between oral status and the extent of coronary artery disease CAD which is diagnosed by angiography
Detailed Description:
Subjects were grouped as CAD or CAD - based on their coronary angiography outcomes Participants were included in CAD if they had more than 50 reduction in diameter in one or more major epicardial arteries whereas patients with less than 50 reduction in epicardial artery diameter were enrolled to CAD - groupThe extent of CAD was measured by the number of main coronary vessels with more than 50 stenosis and occluded left main coronary artery LMCA was also notedDemographic and socioeconomic backgrounds brushing and interdental cleaning habits frequency of dental visits levels of education and medical histories of participants were carefully recorded Medical histories mainly included cardiovascular risk factors consisting of age gender family history of heart disease and myocardial infarction MI smoking habits current medications body mass index BMI hypertension diabetes high density protein HDL and CRP levels BMIs of participants were obtained through dividing weight in kilograms by the square of height in meters Blood samples were collected before angiography in order to analyze biological parameters Hospital records were consulted to obtain patient information such as existence of hypertension hyperlipidemia and diabetes mellitus Education levels were evaluated based on the last school the patient had graduated from and categorized as no education secondary school high school and universityDuring the examination remaining teeth count plaque index PI gingival index GI bleeding on probing BOP and probing pocket depth PPD were analyzed Periodontal measurements were recorded at four sites around each tooth mesial mid-buccal distal and mid-lingual by a periodontal probe excluding third molars Each patient was evaluated for PI GI PPD average scores whole-mouth and percent of BOP sites Oral status was categorized in three groups Group 1 consisted of periodontally healthy subjects and patients with gingivitis Patients having periodontitis were involved in group 2 and group 3 included edentulous subjects Periodontal health was defined as the absence of gingivitis or periodontitis Gingivitis was defined as BOP score of 10 and probing depth of 3mm Diagnosis of periodontitis is based on multiple clinical and radiographic parameters If a patient has one or more sites of inflammation BOP 2mm radiographic bone loss and 4mm probing depth heshe will be diagnosed for periodontitis
For radiographic analysis periapical radiographs were taken from teeth with 4mm PPD using a hand held intra-oral x-ray system operating at 60kVp 15 mA by Dexcowin DX 3000 with a CCD based sensor Trophy RVG ver 50 The alveolar bone loss was measured by a personal computer with the Microsoft Windows XP operating system with original software The site where periodontal ligament terminates at the surface of the root was labeled as the alveolar bone crest Apart from the third molars all teeth were examined to measure the interval between cementoenamel junction and interproximal alveolar crest regarding both mesial and distal aspects of each tooth
For radiographic analysis periapical radiographs were taken from teeth with 4mm PPD using a hand held intra-oral x-ray system operating at 60kVp 15 mA by Dexcowin DX 3000 with a CCD based sensor Trophy RVG ver 50 The alveolar bone loss was measured by a personal computer with the Microsoft Windows XP operating system with original software The site where periodontal ligament terminates at the surface of the root was labeled as the alveolar bone crest Apart from the third molars all teeth were examined to measure the interval between cementoenamel junction and interproximal alveolar crest regarding both mesial and distal aspects of each tooth
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None