Ignite Creation Date:
2024-05-05 @ 4:58 PM
Last Modification Date:
2024-10-26 @ 9:26 AM
Study NCT ID:
NCT00353444
Status:
SUSPENDED
Last Update Posted:
2008-11-06
First Post:
2006-07-17
Brief Title:
Transcranial Doppler Measurement and Prognosis in Moderate Head Injury
Sponsor:
Universidad Autonoma de San Luis Potosí
Organization:
Universidad Autonoma de San Luis Potosí
Study Overview
Official Title:
Transcranial Doppler Measurement and Prognosis in Moderate Head Injury
Status:
SUSPENDED
Status Verified Date:
2008-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Technical Conflicts
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to determine whether Transcranial Doppler measurements have correlation with neuropsychological test Galvestone Orientation Amnesia Test TC image Marshall Scale and prognosis DRS and GOS in moderate head injury
Detailed Description:
The head injury is a frequent problem of health which produces high morbi-mortality Today is the main cause of death and disability between 18 and 40 years In addition it originates expensive expenses in health care systems
Severity of cerebral injury is not only because of impact it is implicated many physiopathological changes Decrease or increase of cerebral blood flow CBF play important roll formation of edema and intracranial hypertension Hypoxicischemic damage is the final point of both changes
The transcranial Doppler TCD was introduced around 1982 Through TCD can be measured the flow velocity of intracranial arteries which let us identify changes in diameter in vessels There are three windows of access to arteries transtemporal transorbitary and suboccipital
The parameter are systolic velocity S tele-diastolic velocity D mean velocity M and pulsatility index PI Many studies have been conducted for evaluate utility in head injury TCD can identify changes that correlate with alteration in CBF intracranial pressure ICP
The autoregulatory status is important TCD with decrement in D and increment in PI could tell us about failure in this issue An invasive way for estimate cerebral perfusion pressure CCP with TCD The most sensible for fall in is amplitude in FV However there is more correlation between CPP and PI Vasospasm can occur post trauma for identify the Lindegaard ratio FVcmaFVcia is useful The other change hyperemia can be demonstrated by continuously increase FV In post traumatic time is very important identify alterations which could produce ischemia The measurement of CPP generally is gotten by invasión with ICP determination
In severe head injury has been demonstrated correlation between ICP and PI strongest for CPP and PI Other parameters are oligaemia and vasospasm in the first 24 hours correlate poor outcome
Because of the non invasive characteristic and good correlation with physiologic and prognosis we think it is important evaluate if there are a kind of correlation between amnesia and orientation prognosis and TCD parameters
Severity of cerebral injury is not only because of impact it is implicated many physiopathological changes Decrease or increase of cerebral blood flow CBF play important roll formation of edema and intracranial hypertension Hypoxicischemic damage is the final point of both changes
The transcranial Doppler TCD was introduced around 1982 Through TCD can be measured the flow velocity of intracranial arteries which let us identify changes in diameter in vessels There are three windows of access to arteries transtemporal transorbitary and suboccipital
The parameter are systolic velocity S tele-diastolic velocity D mean velocity M and pulsatility index PI Many studies have been conducted for evaluate utility in head injury TCD can identify changes that correlate with alteration in CBF intracranial pressure ICP
The autoregulatory status is important TCD with decrement in D and increment in PI could tell us about failure in this issue An invasive way for estimate cerebral perfusion pressure CCP with TCD The most sensible for fall in is amplitude in FV However there is more correlation between CPP and PI Vasospasm can occur post trauma for identify the Lindegaard ratio FVcmaFVcia is useful The other change hyperemia can be demonstrated by continuously increase FV In post traumatic time is very important identify alterations which could produce ischemia The measurement of CPP generally is gotten by invasión with ICP determination
In severe head injury has been demonstrated correlation between ICP and PI strongest for CPP and PI Other parameters are oligaemia and vasospasm in the first 24 hours correlate poor outcome
Because of the non invasive characteristic and good correlation with physiologic and prognosis we think it is important evaluate if there are a kind of correlation between amnesia and orientation prognosis and TCD parameters
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None