Ignite Creation Date:
2024-05-06 @ 1:28 PM
Last Modification Date:
2024-10-26 @ 1:15 PM
Study NCT ID:
NCT04036669
Status:
COMPLETED
Last Update Posted:
2019-07-30
First Post:
2019-07-23
Brief Title:
Adipokines as Predictors of Foot Function Pain and Disability in Patients With Rheumatoid Arthritis
Sponsor:
King Saud University
Organization:
King Saud University
Study Overview
Official Title:
Foot Bone Mineral Density and Inflammation in Rheumatoid Arthritis
Status:
COMPLETED
Status Verified Date:
2019-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Significant increase in the levels of serum adiponectin ADA and hsCRP was reported in all RA patients compared to controls
Compared to patients with early RA the increase in these markers significantly correlated with disease activity DAS-ESR lower f-BMD radiographic scoring pain FFI and functional limitations in patients with established RA
Adiponectin showed a negative correlation with serum levels of both ADA and hsCRP By using ROC curve analysis optimal cut-off values of adiponectin 288 µgml ADA 273 IUL and hsCRP 16 mgL could be used to estimate early RA in 45 of the patients Similarly using cut-off values of adiponectin 328 µgml ADA 261 IUL ml and hsCRP 25 mgL established RA could be predicted in 55 of patients with 98-99 accuracy
Compared to patients with early RA the increase in these markers significantly correlated with disease activity DAS-ESR lower f-BMD radiographic scoring pain FFI and functional limitations in patients with established RA
Adiponectin showed a negative correlation with serum levels of both ADA and hsCRP By using ROC curve analysis optimal cut-off values of adiponectin 288 µgml ADA 273 IUL and hsCRP 16 mgL could be used to estimate early RA in 45 of the patients Similarly using cut-off values of adiponectin 328 µgml ADA 261 IUL ml and hsCRP 25 mgL established RA could be predicted in 55 of patients with 98-99 accuracy
Detailed Description:
The present study attempts to evaluate the efficacy of adiponectin ADA and foot bone mineral density fBMD as predictors of the disease progression in patients with rheumatoid arthritis A total of 80 RA patients and eighty age and sex-matched healthy controls were included in this study
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None