Ignite Creation Date:
2024-05-06 @ 1:28 PM
Last Modification Date:
2024-10-26 @ 1:15 PM
Study NCT ID:
NCT04034940
Status:
UNKNOWN
Last Update Posted:
2019-07-30
First Post:
2019-07-24
Brief Title:
Correlations Between Oxidative Stress Biomarkers h-FABP and Left Ventricular Dysfunction in Patients With Acute Myocardial Infarction Undergoing Primary PCI
Sponsor:
Grigore T Popa University of Medicine and Pharmacy
Organization:
Grigore T Popa University of Medicine and Pharmacy
Study Overview
Official Title:
Correlations Between Oxidative Stress Biomarkers h-FABP and Left Ventricular Dysfunction in Patients With Acute Myocardial Infarction Undergoing Primary PCI
Status:
UNKNOWN
Status Verified Date:
2019-07
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
OxiSTEMIhFABP
Brief Summary:
The investigators intend to evaluate Oxidative Stress biomarkers through a Catalase Activity Assay b Lipid Peroxidation Assay c SOD Assay d Total Antioxidant Capacity Assay e Glutathione Peroxidase at patients with acute myocardial infarction STEMI referred for primary PCI The investigators also aim to evaluate cardiac necrosis by measuring Heart Fatty Acid Binding Protein H-FABP TnI CK CK-MB LDH and AST in these patients with acute myocardial infarction referred for primary PCI Also the investigators intend to evaluate body composition through bioimpedance spectroscopy BCM - Fresenius Care at the moment of admission
The investigators aim to fully characterise these patients through oxidative millieu hFABP and make correlations with LVEF dysfunction
The investigators aim to fully characterise these patients through oxidative millieu hFABP and make correlations with LVEF dysfunction
Detailed Description:
Gathered data
Descriptive general demographic data
Previous pathologies ischemic heart disease peripheral arterial disease stroke heart failure previous percutaneous coronary interventions coronary artery bypass grafting - CABG known renal disease
Cardiovascular risk factors age weight height abdominal perimeter body mass index smoking sedentariness diabetes hypertension dyslipidaemia
Oxidative Stress biomarkers Catalase Activity Assay Lipid Peroxidation Assay SOD Assay Total Antioxidant Capacity Assay Glutathione
Cardiac necrosis markers Heart Fatty Acid Binding Protein H-FABP TnI CK CK-MB LDH and OGT
Routine biological data
Metabolic data obtained from two body composition monitoring evaluations - before and 12 hours after coronary intervention - body water body fat tissue
Information regarding primary PCI less than 12 hours of ischemic symptoms
Coronarographic details type of used stent periprocedural specific complications final TIMI - thrombolysis in myocardial infarction - flow
Echocardiography at admission LVEF
Measurement of arterial stiffness through Sphigmocore pulsed-wave-velocity 24 hrs post-procedural 2 velocities carotid - femoral and carotid - radial
Calculating of cardiovascular risk scores Syntax Score Framingham score ASSIGN score QRISK2 score PROCAM score CRUSADE score GRACE score CHADS VASc score MESA score ASCVD score Hamilton Depression Rating Scale HAM-D Hamilton Rating Scale for Anxiety
In-hospital and one month follow-up MACE
Descriptive general demographic data
Previous pathologies ischemic heart disease peripheral arterial disease stroke heart failure previous percutaneous coronary interventions coronary artery bypass grafting - CABG known renal disease
Cardiovascular risk factors age weight height abdominal perimeter body mass index smoking sedentariness diabetes hypertension dyslipidaemia
Oxidative Stress biomarkers Catalase Activity Assay Lipid Peroxidation Assay SOD Assay Total Antioxidant Capacity Assay Glutathione
Cardiac necrosis markers Heart Fatty Acid Binding Protein H-FABP TnI CK CK-MB LDH and OGT
Routine biological data
Metabolic data obtained from two body composition monitoring evaluations - before and 12 hours after coronary intervention - body water body fat tissue
Information regarding primary PCI less than 12 hours of ischemic symptoms
Coronarographic details type of used stent periprocedural specific complications final TIMI - thrombolysis in myocardial infarction - flow
Echocardiography at admission LVEF
Measurement of arterial stiffness through Sphigmocore pulsed-wave-velocity 24 hrs post-procedural 2 velocities carotid - femoral and carotid - radial
Calculating of cardiovascular risk scores Syntax Score Framingham score ASSIGN score QRISK2 score PROCAM score CRUSADE score GRACE score CHADS VASc score MESA score ASCVD score Hamilton Depression Rating Scale HAM-D Hamilton Rating Scale for Anxiety
In-hospital and one month follow-up MACE
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None