Ignite Creation Date:
2024-05-06 @ 1:26 PM
Last Modification Date:
2024-10-26 @ 1:14 PM
Study NCT ID:
NCT04022824
Status:
UNKNOWN
Last Update Posted:
2021-09-05
First Post:
2019-07-01
Brief Title:
Vascular Responses After Percutaneous Coronary Intervention With Stenting In Patients With Obstructive Sleep Apnea
Sponsor:
Beijing Anzhen Hospital
Organization:
Beijing Anzhen Hospital
Study Overview
Official Title:
Vascular Responses After Percutaneous Coronary Intervention With Stenting In Patients With Obstructive Sleep ApNea A Serial 3-Vessel Optical Coherence Tomography Study VISION
Status:
UNKNOWN
Status Verified Date:
2021-09
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
VISION
Brief Summary:
Obstructive sleep apnea OSA is an increasingly common chronic disorder in adults Compared to the general population OSA occurs more often in patients with coronary artery disease CAD with a reported prevalence of 38 to 65 Emerging evidence indicates OSA initiates and exacerbates coronary atherosclerosis Moreover several observational studies indicate the presence of OSA was associated with higher rate of restenosis and repeat revascularization mainly attributed non-culprit lesion revascularization after percutaneous coronary intervention PCI OSA might initiate endothelial injury by repetitive bursts of sympathetic activity that occur with apneas and hypopneas Moreover untreated OSA reduces endothelial repair capacity Whether OSA could exacerbate neointimal proliferation and plaque progression in the non-culprit lesion after drug-eluting stent DES implantation remains less studied The investigators aimed to evaluate neointimal proliferation and strut coverage within stent segment as well as changes of plaque volume and morphology in the non-culprit lesion by optical coherence tomography OCT in patients with versus without OSA at 12-month follow-up
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None