Ignite Creation Date:
2024-05-06 @ 1:23 PM
Last Modification Date:
2024-10-26 @ 1:13 PM
Study NCT ID:
NCT04009733
Status:
COMPLETED
Last Update Posted:
2023-05-08
First Post:
2019-06-28
Brief Title:
Epigenetic Regulation of Osteogenesis Imperfecta Severity miROI Study
Sponsor:
Hospices Civils de Lyon
Organization:
Hospices Civils de Lyon
Study Overview
Official Title:
Epigenetic Regulation of Osteogenesis Imperfecta Severity miROI Study
Status:
COMPLETED
Status Verified Date:
2023-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
miROI
Brief Summary:
Osteogenesis Imperfecta OI is a heterogeneous group of rare connective tissue hereditary diseases responsible for fragility and bone deformity OI is caused by an autosomal dominant mutation of COL1A1 or COL1A2 encoding α1 and α2 of the collagen regardless of their phenotypic severity 1 to 5 OI type
This observation suggests the existence of a undetermined mechanism that may be found in epigenetic regulation including particularly micro Ribonucleic Acids miRs
Indeed these small non-coding miRs are involved in the regulation of major steps of cellular processes in different pathologies especially in bone disease
Currently no study can provide a satisfactory answer
This is an etiologic study to reveal the correlation between micro-RNAs miR expression and the type I or III of the Osteogenesis Imperfecta OI
The aim of this study is therefore to identify miRs significantly associated with the severity of OI
This observation suggests the existence of a undetermined mechanism that may be found in epigenetic regulation including particularly micro Ribonucleic Acids miRs
Indeed these small non-coding miRs are involved in the regulation of major steps of cellular processes in different pathologies especially in bone disease
Currently no study can provide a satisfactory answer
This is an etiologic study to reveal the correlation between micro-RNAs miR expression and the type I or III of the Osteogenesis Imperfecta OI
The aim of this study is therefore to identify miRs significantly associated with the severity of OI
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 2019-A00521-56 | OTHER | ID-RCB | None |