Ignite Creation Date:
2024-05-05 @ 4:57 PM
Last Modification Date:
2024-10-26 @ 9:26 AM
Study NCT ID:
NCT00357058
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
2006-07-26
Brief Title:
Role of Brain Region Changes in Tactile Touch Ability Following Nerve Block
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Substrates Mediating Deafferentiation-Induced Enhancement of Tactile Spatial Acuity
Status:
COMPLETED
Status Verified Date:
2007-12-28
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will examine the role of different brain regions in tactile touch ability after application of a tourniquet inflated blood pressure cuff When the forearm is deprived of blood for a short period of time tactile ability in the other hand improves This study will try to learn what causes this improvement
Healthy normal volunteers are eligible for this study Candidates will have a brief medical history and physical examination
Volunteers will undergo two experiments described below that involve the following procedures
Ischemic nerve block - A blood pressure cuff is inflated for 35-40 minutes around the elbow area also around the calf for Experiment 2 - see below The resulting numbness tingling loss of muscle strength and discoloration of the forearm and hand disappear within minutes after the cuff is deflated
Magnetic resonance imaging MRI - This test uses a magnetic field and radio waves instead of X-rays to produce images of brain structure and function The volunteer lies on a stretcher that is moved into the scanner a cylinder containing a strong magnet wearing earplugs to protect the ears from loud thumping noises that occur with electrical switching of radio frequency circuits The subject can communicate with an investigator by intercom at all times during the scan
Transcranial magnetic stimulation TMS - An insulated wire coil is placed on the patients scalp A brief electrical current passes through the coil creating a magnetic pulse that travels through the scalp and skull and causes small electrical currents in the outer part of the brain The stimulation may cause muscle hand or arm twitching or transient tingling in the forearm head or face muscles
Tactile spatial acuity testing - The subjects left arm is placed in a cast and the left index finger is immobilized for this test which involves identifying the direction of grooves applied to the finger
Experiment 1
This experiment measures changes in tactile acuity and brain activation following cuff inflation The subject lies in the MRI scanner with the left arm immobilized Tactile acuity is measured repetitively at the left index finger during placement and inflation of a pressure cuff around the right forearm The experiment consists of two sessions with the cuff around the forearm and one with the cuff around the calf and lasts from 90 minutes to 2 hours
Experiment 2
This experiment measures changes in tactile acuity linked to TMS stimulation The subject sits in an armchair with the left arm immobilized Tactile acuity is measured repetitively at the left index finger during placement and inflation of a pressure cuff around the right forearm In addition TMS pulses about one pulse per second are delivered at different locations over the right side of the head for up to 30 minutes The experiment consists of 10 separate sessions on different days each lasting about 1 hour
Healthy normal volunteers are eligible for this study Candidates will have a brief medical history and physical examination
Volunteers will undergo two experiments described below that involve the following procedures
Ischemic nerve block - A blood pressure cuff is inflated for 35-40 minutes around the elbow area also around the calf for Experiment 2 - see below The resulting numbness tingling loss of muscle strength and discoloration of the forearm and hand disappear within minutes after the cuff is deflated
Magnetic resonance imaging MRI - This test uses a magnetic field and radio waves instead of X-rays to produce images of brain structure and function The volunteer lies on a stretcher that is moved into the scanner a cylinder containing a strong magnet wearing earplugs to protect the ears from loud thumping noises that occur with electrical switching of radio frequency circuits The subject can communicate with an investigator by intercom at all times during the scan
Transcranial magnetic stimulation TMS - An insulated wire coil is placed on the patients scalp A brief electrical current passes through the coil creating a magnetic pulse that travels through the scalp and skull and causes small electrical currents in the outer part of the brain The stimulation may cause muscle hand or arm twitching or transient tingling in the forearm head or face muscles
Tactile spatial acuity testing - The subjects left arm is placed in a cast and the left index finger is immobilized for this test which involves identifying the direction of grooves applied to the finger
Experiment 1
This experiment measures changes in tactile acuity and brain activation following cuff inflation The subject lies in the MRI scanner with the left arm immobilized Tactile acuity is measured repetitively at the left index finger during placement and inflation of a pressure cuff around the right forearm The experiment consists of two sessions with the cuff around the forearm and one with the cuff around the calf and lasts from 90 minutes to 2 hours
Experiment 2
This experiment measures changes in tactile acuity linked to TMS stimulation The subject sits in an armchair with the left arm immobilized Tactile acuity is measured repetitively at the left index finger during placement and inflation of a pressure cuff around the right forearm In addition TMS pulses about one pulse per second are delivered at different locations over the right side of the head for up to 30 minutes The experiment consists of 10 separate sessions on different days each lasting about 1 hour
Detailed Description:
Acute deafferentation in one hand leads to improvements in tactile discriminative skills in the other non-deafferented hand This phenomenon recently identified in our laboratory represents an adaptive behaviorally important consequence of deafferentation It demonstrates that acute loss of sensory input from one hand results in rapid improvement of skills in the remaining hand The first experiment in this protocol seeks to identify cortical regions activated in association with this improvement in tactile spatial acuity In the second experiment we will determine the effects of transient inactivation of focal cortical regions on this behavioral gain While the first experiment will characterize brain regions activated in association with this performance improvement the second experiment will provide information on the functional role of these regions Understanding the substrates that mediate this behavioral gain may be important for the design of strategies to enhance them
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 02-N-0079 | None | None | None |