Ignite Creation Date:
2024-05-06 @ 1:21 PM
Last Modification Date:
2024-10-26 @ 1:13 PM
Study NCT ID:
NCT04008225
Status:
COMPLETED
Last Update Posted:
2019-07-08
First Post:
2019-07-02
Brief Title:
Study of the Effects of Bronchoalveolar Lavage Liquid in the ARDS on the Functioning of the Neutrophil Polynuclear System
Sponsor:
Rennes University Hospital
Organization:
Rennes University Hospital
Study Overview
Official Title:
Study of the Effects of Bronchoalveolar Lavage Liquid in the ARDS on the Functioning of the Neutrophil Polynuclear System
Status:
COMPLETED
Status Verified Date:
2019-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
BALARDS
Brief Summary:
Firstly the study assesses the effect of bronchoalveolar lavage fluid BAL from patients in acute respiratory distress syndrome ARDS on the life span of PNNs and on the phagocytosis of apoptotic cells by macrophages and polynuclear neutrophil PNN
Then the effect of an antibody directed against high-mobility group box 1 protein HMGB1 and the effect of metformin on efferocytosis are studied
Then the effect of an antibody directed against high-mobility group box 1 protein HMGB1 and the effect of metformin on efferocytosis are studied
Detailed Description:
ARDS acute respiratory distress syndrome is a syndrome that causes significant mortality and morbidity This syndrome is characterized by an alveolitis with polynuclear neutrophil PNN PNNs play an important role in the persistence and in injuries induced by ARDS Several animal studies have shown that lesional edema can be increased by two important mechanisms the increase in the lifespan of PNNs in the lung and the decrease in the phagocytosis capacities of apoptotic cells efferocytosis by macrophages and PNNs
However confirmation of these data in humans does not exist and knowledge of the mechanisms that may increase lung damage during ARDS will limit it and thus reduce the mechanical ventilation time of these patients as well as the mortality associated with ARDS
high-mobility group box 1 HMGB1 protein may be involved in reducing efferocytosis capacity Similarly activation of AMP-activated protein kinase AMPk could restore the clearance capacity of apoptotic cells in macrophages and PNNs
However confirmation of these data in humans does not exist and knowledge of the mechanisms that may increase lung damage during ARDS will limit it and thus reduce the mechanical ventilation time of these patients as well as the mortality associated with ARDS
high-mobility group box 1 HMGB1 protein may be involved in reducing efferocytosis capacity Similarly activation of AMP-activated protein kinase AMPk could restore the clearance capacity of apoptotic cells in macrophages and PNNs
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None