Ignite Creation Date:
2024-05-06 @ 1:18 PM
Last Modification Date:
2024-10-26 @ 1:11 PM
Study NCT ID:
NCT03982836
Status:
UNKNOWN
Last Update Posted:
2019-06-12
First Post:
2019-05-21
Brief Title:
Impact of Different Dietary Fibers in Gastric Emptying Time and Intestinal Transit of Healthy Volunteers
Sponsor:
Federal University of Minas Gerais
Organization:
Federal University of Minas Gerais
Study Overview
Official Title:
Impact of Different Dietary Fibers in Gastric Emptying Time and Intestinal Transit of Healthy Volunteers
Status:
UNKNOWN
Status Verified Date:
2019-06
Last Known Status:
ACTIVE_NOT_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The digestive process begins in the mouth and follows in the stomach and intestine In the stomach the food is mixed with the gastric juices forming the chyme To mix the food with the gastric juice as well as to provide gastric emptying GE the movements of the stomach are of great importance Intestinal transit time is understood of the combination of GE small intestine transit and colon transit time The composition of the diet lipid and protein content exerts a direct influence on intestinal transit time due to the stimulation of hormone secretion cholecystokinin and gastrin respectively which act to decrease GE velocity In this context it is also observed an important influence of dietary fibers on the speed of GE Despite all knowledge about dietary fibers information on such compounds still has many controversies Due to the difficulty of finding compounds that fit into only one specific category viscous fermentable or prebiotic there is difficulty in establishing a concept that best defines what are dietary fibers The CODEX Alimentarius Commission in 2009 defined dietary fibers as carbohydrate polymers composed of ten or more monomer units of this macronutrient which are not hydrolyzed by enzymes in the human intestine Dietary fibers can be classified into insoluble and soluble according to the ability to bind to water molecules and form gels Soluble fibers especially those classified as prebiotic in the intestine are fermented by bacteria giving rise to short chain fatty acids SCFA The SCFA stimulates the production and secretion of PYY and GLP-1 are associated with inhibition of gastric motility Due to the importance of knowing the intestinal transit time several methods have been developed but scintigraphy is the gold standard technique for this analysis Given the above and controversies present in the literature on the dietary fibers there was a shortage of studies with the objective of evaluating the impact of different dietary fibers in intestinal transit time This study shows relevant to help elucidate the behavior of different dietary fibers in intestinal transit time offering data for correct and safe use of dietary fibers in various clinical situations The hypothesis of this study is that the partially hydrolyzed guar gum delays the time of gastric emptying and intestinal transit being this effect not observed for fructooligosaccharide
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None