Ignite Creation Date:
2024-05-05 @ 4:56 PM
Last Modification Date:
2024-10-26 @ 9:26 AM
Study NCT ID:
NCT00353483
Status:
RECRUITING
Last Update Posted:
2024-03-18
First Post:
2006-07-17
Brief Title:
Effect of Neoadjuvant or Adjuvant Systemic Therapy on Breast Cancers Bone Marrow Cancer Cells and Circulating Cancer Cells
Sponsor:
Washington University School of Medicine
Organization:
Washington University School of Medicine
Study Overview
Official Title:
Effect of Neoadjuvant or Adjuvant Systemic Therapy on Breast Cancers Bone Marrow Cancer Cells and Circulating Cancer Cells
Status:
RECRUITING
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The main purpose of this study is to compare genetic markers present on tumor cells before and after chemotherapy
Detailed Description:
In this study the investigators propose that persistent disseminated tumor cells DTC present after systemic therapy represent a unique subpopulation of all DTC are predictors of a poor response to systemic therapy and correlate with poor clinical outcome The investigators hypothesize that systemic therapy-resistant DTC can be identified by their expression of a unique constellation of tumor marker proteins which may be similar to those expressed by breast cancer stem cells In this research the investigators specific aims are 1 to characterize tumor markers expressed by DTC which are present after systemic therapy 2 to compare the expression of these markers to that on DTC detected prior to systemic therapy 3 to correlate expression of the defined tumor markers on DTC with clinical outcome of breast cancer patients to identify those markers that are predictive of disease recurrence 4 to utilize biomarkers identified in Specific Aims 1 and 2 to isolate purified DTC for further molecular analysis
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None