Ignite Creation Date:
2024-05-06 @ 1:18 PM
Last Modification Date:
2024-10-26 @ 1:12 PM
Study NCT ID:
NCT03989817
Status:
COMPLETED
Last Update Posted:
2020-08-20
First Post:
2019-06-14
Brief Title:
The Effects of a Long-lasting Infusion of Vasoactive Intestinal Peptide VIP on Headache Cranial Hemodynamic and Autonomic Symptoms in Healthy Volunteers
Sponsor:
Danish Headache Center
Organization:
Danish Headache Center
Study Overview
Official Title:
The Effects of a Long-lasting Infusion of Vasoactive Intestinal Peptide VIP on Headache Cranial Hemodynamic in Healthy Volunteers
Status:
COMPLETED
Status Verified Date:
2020-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Vasoactive intestinal peptide VIP is a peptide of 28 amino acid residues that belongs to the glucagonsecretin superfamily of peptides It is produced in different regions of the nervous system including the brain trigeminovascular system and several autonomic nerves Once released from neurons it acts on vasoactive intestinal peptide receptor 1 VPAC1 vasoactive intestinal peptide receptor 2 VPAC2 and pituitary adenylate cyclase-activating polypeptide type I receptor PAC1 by mediating smooth muscle relaxation vasodilation and water secretion Along with other neuropeptides such as calcitonin gene-related peptide CGRP and pituitary adenylate cyclase-activating polypeptide PACAP it is released from the trigeminal afferents and exerts a strong vasodilating activity on the cranial vasculature sharing the activation of adenylate cyclase Especially it shares 70 structure with PACAP and acts on the same receptors But unlike it VIP cannot induce a long-lasting vasodilation and has a modest capability to induce migraine attacks Whether a long-lasting infusion of VIP may induce a prolonged vasodilation in the cerebral vessels and migraine as a twenty-minute infusion of PACAP is unknown
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None