Ignite Creation Date:
2024-05-06 @ 1:17 PM
Last Modification Date:
2024-10-26 @ 1:12 PM
Study NCT ID:
NCT03986684
Status:
COMPLETED
Last Update Posted:
2022-12-27
First Post:
2019-06-07
Brief Title:
Molecules Associated With the Presence and Severity of Nonalcoholic Fatty Liver Disease
Sponsor:
Hippocration General Hospital
Organization:
Hippocration General Hospital
Study Overview
Official Title:
Targeted Analysis of Three Hormonal Systems Identifies Molecules Associated With the Presence and Severity of Nonalcoholic Fatty Liver Disease
Status:
COMPLETED
Status Verified Date:
2022-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
NAFLD
Brief Summary:
Non-invasive diagnosis and treatment of nonalcoholic fatty liver disease NAFLD remain unmet medical needs Aim of this study is to investigate the blood levels of three hormonal systems related to obesity insulin resistance and inflammation in patients with different stages of NAFLD in order to identify potential diagnostic markers
Study aim To compare the blood levels of a proglucagon-derived hormones glucagon-like peptide GLP-1 GLP-2 glicentin oxyntomodulin glucagon major proglucagon fragment MPGF b follistatins-activins follistatin-like FSTL3 activin B c IGF axis insulin-like growth factor IGF-1 total and intact IGF binding protein IGFBP-3 and IGFBP-4 in 18 individuals with early stage NAFLD vs 14 controls To explore the levels of GDF-15 total and intact in NAFLD versus obese controls OC at baseline and during oral glucose tolerance tests OGTTs
Study aim To compare the blood levels of a proglucagon-derived hormones glucagon-like peptide GLP-1 GLP-2 glicentin oxyntomodulin glucagon major proglucagon fragment MPGF b follistatins-activins follistatin-like FSTL3 activin B c IGF axis insulin-like growth factor IGF-1 total and intact IGF binding protein IGFBP-3 and IGFBP-4 in 18 individuals with early stage NAFLD vs 14 controls To explore the levels of GDF-15 total and intact in NAFLD versus obese controls OC at baseline and during oral glucose tolerance tests OGTTs
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None