Viewing Study NCT03974529



Ignite Creation Date: 2024-05-06 @ 1:16 PM
Last Modification Date: 2024-10-26 @ 1:11 PM
Study NCT ID: NCT03974529
Status: UNKNOWN
Last Update Posted: 2019-06-05
First Post: 2019-04-17

Brief Title: Intensive Running Exercise Improves Parkinsons Motor and Non-motor Symptoms
Sponsor: Chinese University of Hong Kong
Organization: Chinese University of Hong Kong

Study Overview

Official Title: Intensive Running Exercise Improves Parkinsons Motor and Non-motor Symptoms
Status: UNKNOWN
Status Verified Date: 2019-06
Last Known Status: RECRUITING
Delayed Posting: No
If Stopped, Why?: Not Stopped
Has Expanded Access: False
If Expanded Access, NCT#: N/A
Has Expanded Access, NCT# Status: N/A
Acronym: None
Brief Summary: High quality clinical trial and meta-analysis have demonstrated short term and to a lesser extent long term benefits in various outcome measures To achieve positive effects supervised progressive strength and aerobic endurance training program of 12 weeks was required Extended progressive strength training improved muscle strength for up to 24 months While aerobic endurance training would increase walking capacity up to 16 months 1 There are data suggesting a threshold of intensity of exercise to be reached for the positive effect This overall body of evidence suggests that regular vigorous exercise should be accorded a central place in the treatment of Parkinsons disease

However there was no evidence about regular intensive exercise of running in Parkinsons disease And most of the studies were not randomized with a control group

In this study the investigators are to investigate the effect of regular vigorous aerobic exercise training of running on motor and non-motor symptoms and quality-of-life of people with Parkinsons disease
Detailed Description: There is growing volume of evidences support the positive effect of exercise and physical therapy to Parkinsons disease Various exercise types have shown different positive effects Gait training for 4 weeks showed a moderate improvement in balancing while balance training of 8 to 26 weeks decreased fall rate Cued exercise would mildly increase the speed of the gait Complementary exercises such as Tai Chi and dancing have shown improvement in balancing of the patients

One of the main complaints of Parkinsons disease is rigidity It is because of the musculoskeletal impairments which compromise the flexibility and stability of both axial structure spine and the extremities Truncal stiffness and rigidity results in a stooped posture which further undermines ones balance and agility Flexibility training stretching is shown to be beneficial to all stages of patients with Parkinsons disease in terms of improved both range of movement in joints and spinal stability It is recommended that regular stretching should be the first step in ones exercise program to combat the muscle rigidity High quality clinical trial and meta-analysis have demonstrated short term and to a lesser extent long term benefits in various outcome measures To achieve positive effects supervised progressive strength and aerobic endurance training program of 12 weeks was required Extended progressive strength training improved muscle strength for up to 24 months While aerobic endurance training would increase walking capacity up to 16 months

There are data suggested a threshold of intensity of exercise to be reached for the positive effect This overall body of evidence suggests that regular vigorous exercise should be accorded a central place in the treatment of Parkinsons disease

In this study the investigators are to investigate the effect of regular vigorous aerobic exercise training of running on motor and non-motor symptoms and quality-of-life of people with Parkinsons disease

Study Oversight

Has Oversight DMC: None
Is a FDA Regulated Drug?: False
Is a FDA Regulated Device?: False
Is an Unapproved Device?: None
Is a PPSD?: None
Is a US Export?: None
Is an FDA AA801 Violation?: None
Secondary IDs
Secondary ID Type Domain Link
NTEC-2018-0330 REGISTRY Joint CUHK-NTEC Clinical Research Ethics Committee CREC None