Ignite Creation Date:
2024-05-06 @ 1:12 PM
Last Modification Date:
2024-10-26 @ 1:10 PM
Study NCT ID:
NCT03965520
Status:
UNKNOWN
Last Update Posted:
2019-05-29
First Post:
2019-05-17
Brief Title:
Exercise Test and Sequential Training Strategies in PAD
Sponsor:
Chang Gung Memorial Hospital
Organization:
Chang Gung Memorial Hospital
Study Overview
Official Title:
Exercise Test and Sequential Training Strategies in Peripheral Arterial Disease
Status:
UNKNOWN
Status Verified Date:
2019-05
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Diabetic lower extremity disease including peripheral vascular disease peripheral neuropathy foot ulcers or leg amputation Among them peripheral arterial disease PAD is an important expression of systemic atherosclerosis With the progress of the disease impaired peripheral blood circulation will lead to many symptoms and signs such as pain paresthesia and numbness
In past studies show that regular exercise with moderate intensity may help to improve metabolism and hemodynamic characteristics of the individual In addition many studies have found that despite substantial organic changes in downstream tissue exercise training can improve walking ability and aerobic capacity in patients with peripheral arterial disease
To enhance exercise capacity in patients with PAD may involve redistribution of blood flow from vascular beds with lower O 2 exchange rates towards exercising ischemic muscles an increase in nutritive leg muscle blood flow at the expense of regional shunting mechanisms increased peripheral O 2 use during exercise attributable to more optimal distribution of leg blood flow and possible increased muscle capillary density and mitochondrial capacity
Therefore we tried to mimic local leg ischemic- reperfusion by systemic exercise or to practice remote preconditioning effect by interval occlusion of the blood vessel in the upper arm which acquired ischemic preconditioning effect and to improve local blood flow Furthermore the hemagglutination performance in PAD patients may also be used as an important indicator of cardiovascular disease
In past studies show that regular exercise with moderate intensity may help to improve metabolism and hemodynamic characteristics of the individual In addition many studies have found that despite substantial organic changes in downstream tissue exercise training can improve walking ability and aerobic capacity in patients with peripheral arterial disease
To enhance exercise capacity in patients with PAD may involve redistribution of blood flow from vascular beds with lower O 2 exchange rates towards exercising ischemic muscles an increase in nutritive leg muscle blood flow at the expense of regional shunting mechanisms increased peripheral O 2 use during exercise attributable to more optimal distribution of leg blood flow and possible increased muscle capillary density and mitochondrial capacity
Therefore we tried to mimic local leg ischemic- reperfusion by systemic exercise or to practice remote preconditioning effect by interval occlusion of the blood vessel in the upper arm which acquired ischemic preconditioning effect and to improve local blood flow Furthermore the hemagglutination performance in PAD patients may also be used as an important indicator of cardiovascular disease
Detailed Description:
Diabetic lower extremity disease including peripheral vascular disease peripheral neuropathy foot ulcers or leg amputation Among them peripheral arterial disease PAD is an important expression of systemic atherosclerosis With the progress of the disease impaired peripheral blood circulation will lead to many symptoms and signs such as pain paresthesia and numbness
In past studies show that regular exercise with moderate intensity may help to improve metabolism and hemodynamic characteristics of the individual In addition many studies have found that despite substantial organic changes in downstream tissue exercise training can improve walking ability and aerobic capacity in patients with peripheral arterial disease
To enhance exercise capacity in patients with PAD may involve redistribution of blood flow from vascular beds with lower O 2 exchange rates towards exercising ischemic muscles an increase in nutritive leg muscle blood flow at the expense of regional shunting mechanisms increased peripheral O 2 use during exercise attributable to more optimal distribution of leg blood flow and possible increased muscle capillary density and mitochondrial capacity
Therefore we tried to mimic local leg ischemic- reperfusion by systemic exercise or to practice remote preconditioning effect by interval occlusion of the blood vessel in the upper arm which acquired ischemic preconditioning effect and to improve local blood flow Furthermore the hemagglutination performance in PAD patients may also be used as an important indicator of cardiovascular disease
In past studies show that regular exercise with moderate intensity may help to improve metabolism and hemodynamic characteristics of the individual In addition many studies have found that despite substantial organic changes in downstream tissue exercise training can improve walking ability and aerobic capacity in patients with peripheral arterial disease
To enhance exercise capacity in patients with PAD may involve redistribution of blood flow from vascular beds with lower O 2 exchange rates towards exercising ischemic muscles an increase in nutritive leg muscle blood flow at the expense of regional shunting mechanisms increased peripheral O 2 use during exercise attributable to more optimal distribution of leg blood flow and possible increased muscle capillary density and mitochondrial capacity
Therefore we tried to mimic local leg ischemic- reperfusion by systemic exercise or to practice remote preconditioning effect by interval occlusion of the blood vessel in the upper arm which acquired ischemic preconditioning effect and to improve local blood flow Furthermore the hemagglutination performance in PAD patients may also be used as an important indicator of cardiovascular disease
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None