Ignite Creation Date:
2024-05-05 @ 11:08 AM
Last Modification Date:
2024-10-26 @ 9:04 AM
Study NCT ID:
NCT00004334
Status:
UNKNOWN
Last Update Posted:
2005-06-24
First Post:
1999-10-18
Brief Title:
Study of Depression Peptides and Steroids in Cushings Syndrome
Sponsor:
National Center for Research Resources NCRR
Organization:
National Center for Research Resources NCRR
Study Overview
Official Title:
None
Status:
UNKNOWN
Status Verified Date:
2003-12
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
OBJECTIVES I Study the relationship between dysregulation of the hypothalamic-pituitary-adrenal HPA axis and disorders of mood vegetative function and cognition in patients with Cushings disease
II Identify subgroups of patients with Cushings disease who differ in the presence and severity of the depressive syndrome and uncover HPA axis dysregulation differences among them using corticotropin-releasing hormone metyrapone and dexamethasone challenge testing
II Identify subgroups of patients with Cushings disease who differ in the presence and severity of the depressive syndrome and uncover HPA axis dysregulation differences among them using corticotropin-releasing hormone metyrapone and dexamethasone challenge testing
Detailed Description:
PROTOCOL OUTLINE All patients receive a psychiatric evaluation at baseline as well as assessments of plasma adrenocorticotropin beta lipotropin beta endorphin and cortisol and urinary cortisol Peptide and steroid assays are performed alone and in response to corticotropin-releasing hormone metyrapone and dexamethasone Patients are given sleep electroencephalograms at baseline and 1 year following treatment
A weight maintenance diet is prescribed for all patients
A weight maintenance diet is prescribed for all patients
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| UMMC-701 | None | None | None |