Ignite Creation Date:
2024-05-05 @ 4:56 PM
Last Modification Date:
2024-10-26 @ 9:25 AM
Study NCT ID:
NCT00342784
Status:
COMPLETED
Last Update Posted:
2018-08-01
First Post:
2006-06-19
Brief Title:
Identification of Prostate Cancer Genes
Sponsor:
National Human Genome Research Institute NHGRI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Genetic Analysis of Cases Controls and Families With Prostate Cancer
Status:
COMPLETED
Status Verified Date:
2018-07-30
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will identify genes that predispose men to prostate cancer and affect the rate and type of disease spread the aggressiveness of the disease and the long-term outcome Several studies show there is a genetic component to prostate cancer susceptibility and that a first-degree relative with prostate cancer increases a mans risk 2- to 3-fold compared to those without a family history The risk is significantly higher if the relative was diagnosed at younger than 65 years of age or if three or more first-degree relatives are affected
The study will try to locate prostate cancer genes in DNA samples using two methods linkage analysis and association studies Traditionally the search for a disease gene begins with linkage analysis in which the aim is to find the rough location of the gene relative to another DNA sequence called a genetic marker whose position is already known In genetic association studies genes from a large number of patients are compared with healthy controls who are matched by age race and geographic region
DNA samples for this study come from patients in the two following studies at the Fred Hutchinson Cancer Research Center Seattle Washington
Family study Participants are families with prostate cancer who have 1 three or more first-degree relatives with prostate cancer 2 three generations with prostrate cancer either through the maternal or paternal side of the family or 3 two first-degree relatives with prostate cancer diagnosed before age 65 or who were African American
Population-based study Participants are patients with prostate cancer and matched healthy control subjects
The identification of prostate cancer genes important in susceptibility to the disease and its aggressiveness may permit earlier detection and development of more directed and effective treatments based on underlying genetics
The study will try to locate prostate cancer genes in DNA samples using two methods linkage analysis and association studies Traditionally the search for a disease gene begins with linkage analysis in which the aim is to find the rough location of the gene relative to another DNA sequence called a genetic marker whose position is already known In genetic association studies genes from a large number of patients are compared with healthy controls who are matched by age race and geographic region
DNA samples for this study come from patients in the two following studies at the Fred Hutchinson Cancer Research Center Seattle Washington
Family study Participants are families with prostate cancer who have 1 three or more first-degree relatives with prostate cancer 2 three generations with prostrate cancer either through the maternal or paternal side of the family or 3 two first-degree relatives with prostate cancer diagnosed before age 65 or who were African American
Population-based study Participants are patients with prostate cancer and matched healthy control subjects
The identification of prostate cancer genes important in susceptibility to the disease and its aggressiveness may permit earlier detection and development of more directed and effective treatments based on underlying genetics
Detailed Description:
The notion that there are prostate cancer susceptibility genes has since been suggested by case-control cohort and twin studies The effect is strongest among first-degree relatives where the relative risk estimates range from 17 to 37 Families reporting younger ages at diagnosis and multiple relatives with prostate cancer were demonstrated even higher relative risks For example compared to men with no family history men with three or more first-degree relatives with prostate cancer have almost an 11-fold increased risk Although the majority of studies focused on Caucasians similar elevations in risk associated with a family history of disease have been reported for Asian and African Americans While the majority of the data seems to point towards autosomal dominant genes evidence for an X-linked or recessive inheritance has also been reported
During the last decade others and we have been devoted to the search for hereditary prostate cancer HPC loci either by linkage or by association with candidate genes A generally agreed upon definition of HPC families now exists These are families in which there is either 1 prostate cancer in three or more first-degree relatives 2 prostate cancer in three successive generations or 3 a cluster of two relatives diagnosed at less than or equal to 55 years
Armed with these criteria others and we have collected large data sets of likely hereditary families and undertaken genome wide scans However locus heterogeneity issues have made the task difficult There are clearly many genes that contribute to prostate cancer susceptibility and many are likely to be weakly penetrant We have stratified the data derived from our genome scan by a number of likely factors such as age at diagnosis number of affected men founder effects aggressiveness of disease and presence of other cancers in the family to develop more homogeneous datasets We propose to continue those sorts of studies as well as focus on cloning genes in regions we and others have identified to date To test hypotheses that certain variants are associated with prostate cancer susceptibility or progression of disease will also conduct association studies in a population-based case control study of middle aged men with prostate cancer This will allow us to test the putative association of candidate genes and SNPs in prostate cancer susceptibility aggressivity and long-term outcomes
During the last decade others and we have been devoted to the search for hereditary prostate cancer HPC loci either by linkage or by association with candidate genes A generally agreed upon definition of HPC families now exists These are families in which there is either 1 prostate cancer in three or more first-degree relatives 2 prostate cancer in three successive generations or 3 a cluster of two relatives diagnosed at less than or equal to 55 years
Armed with these criteria others and we have collected large data sets of likely hereditary families and undertaken genome wide scans However locus heterogeneity issues have made the task difficult There are clearly many genes that contribute to prostate cancer susceptibility and many are likely to be weakly penetrant We have stratified the data derived from our genome scan by a number of likely factors such as age at diagnosis number of affected men founder effects aggressiveness of disease and presence of other cancers in the family to develop more homogeneous datasets We propose to continue those sorts of studies as well as focus on cloning genes in regions we and others have identified to date To test hypotheses that certain variants are associated with prostate cancer susceptibility or progression of disease will also conduct association studies in a population-based case control study of middle aged men with prostate cancer This will allow us to test the putative association of candidate genes and SNPs in prostate cancer susceptibility aggressivity and long-term outcomes
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 05-HG-N034 | None | None | None |