Ignite Creation Date:
2024-05-05 @ 4:56 PM
Last Modification Date:
2024-10-26 @ 9:25 AM
Study NCT ID:
NCT00340392
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
2006-06-19
Brief Title:
Isolation and Characterization of Mammary Stem Cells
Sponsor:
National Cancer Institute NCI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Isolation and Characterization of Mammary Stem Cells
Status:
COMPLETED
Status Verified Date:
2011-03-23
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Background
Cancer stem cells in breast cancer have been identified as a small population of tumor cells whose self-renewal mechanism is highly deregulated This deregulation seems to be necessary for cancer to develop
These cells can be identified by certain surface markers that overlap with markers associated with normal embryonic stem cells
Objective To isolate tumor stem cells using the same methods generally used to isolate human embryonic stem cells
Eligibility
Tissue samples will be obtained from the human cooperative network
Samples will include normal tissues from individuals who have no opportunistic diseases and from individuals with cancer
Design Breast cancer stem cells will be isolated grown in the laboratory and characterized
Cancer stem cells in breast cancer have been identified as a small population of tumor cells whose self-renewal mechanism is highly deregulated This deregulation seems to be necessary for cancer to develop
These cells can be identified by certain surface markers that overlap with markers associated with normal embryonic stem cells
Objective To isolate tumor stem cells using the same methods generally used to isolate human embryonic stem cells
Eligibility
Tissue samples will be obtained from the human cooperative network
Samples will include normal tissues from individuals who have no opportunistic diseases and from individuals with cancer
Design Breast cancer stem cells will be isolated grown in the laboratory and characterized
Detailed Description:
Cancers are composed of heterogeneous populations of cells with varying degrees of proliferative capacity and ability to reconstitute tumors when transplanted into nude or SCID mice
Recently cancer stem cells have been identified as a small population of tumor cells which possess the stem cell properties in that their self-renewal pathway is highly deregulated This deregulation seems to be the prerequisite for the development of cancer
Recently cancer stem cells have been identified as a small population of tumor cells which possess the stem cell properties in that their self-renewal pathway is highly deregulated This deregulation seems to be the prerequisite for the development of cancer
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 06-C-N140 | None | None | None |