Ignite Creation Date:
2024-05-05 @ 11:08 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005525
Status:
COMPLETED
Last Update Posted:
2016-03-16
First Post:
2000-05-25
Brief Title:
Sleep Apnea in Elderly Male Twins
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2005-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To conduct a genetic analysis of anatomic risk factors for sleep apnea in a well-characterized United States population-based registry of elderly male twins who have been successfully followed for the past 30 years
Detailed Description:
BACKGROUND
The contribution of genetic factors to sleep disorders has been demonstrated in twin and family studies and further understanding of the genetic underpinning of sleep disorders is considered an important area of research Many of the suggested risk factors for sleep apnea egcraniofacial morphology obesity have genetic determinants However a formal genetic analysis of these anatomical risk factors with sleep-recorded physiological measurements has not so far been conducted
DESIGN NARRATIVE
The investigators recruited a subsample of pairs from the NAS-NRC World War II Twin Registry in which at least one of the twin brothers reported sleep apnea symptoms and a subsample of control pairs in which both twins reported no symptoms They monitoring the subgroup of twin pairs with overnight sleep recording They also collected anthropometric measurements of weight height neck circumference and craniofacial morphology and blood samples for determination of zygosity and DNA extraction for future molecular studies
The twin design is most powerful for estimating the genetic andor environmental overlap between physiological measurements such as sleep-recorded disordered breathing obesity and craniofacial morphology The investigators chose to focus on an elderly male twin sample for which a wealth of data relevant to this study had been previously collected Twin pair concordance or discordance for monitored sleep-disordered breathing allowed the full characterization of geneticfamilial and individual environmental factors associated with the expression and severity of this condition
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
The contribution of genetic factors to sleep disorders has been demonstrated in twin and family studies and further understanding of the genetic underpinning of sleep disorders is considered an important area of research Many of the suggested risk factors for sleep apnea egcraniofacial morphology obesity have genetic determinants However a formal genetic analysis of these anatomical risk factors with sleep-recorded physiological measurements has not so far been conducted
DESIGN NARRATIVE
The investigators recruited a subsample of pairs from the NAS-NRC World War II Twin Registry in which at least one of the twin brothers reported sleep apnea symptoms and a subsample of control pairs in which both twins reported no symptoms They monitoring the subgroup of twin pairs with overnight sleep recording They also collected anthropometric measurements of weight height neck circumference and craniofacial morphology and blood samples for determination of zygosity and DNA extraction for future molecular studies
The twin design is most powerful for estimating the genetic andor environmental overlap between physiological measurements such as sleep-recorded disordered breathing obesity and craniofacial morphology The investigators chose to focus on an elderly male twin sample for which a wealth of data relevant to this study had been previously collected Twin pair concordance or discordance for monitored sleep-disordered breathing allowed the full characterization of geneticfamilial and individual environmental factors associated with the expression and severity of this condition
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL059659 | NIH | None | httpsreporternihgovquickSearchR01HL059659 |