Ignite Creation Date:
2024-05-06 @ 1:10 PM
Last Modification Date:
2024-10-26 @ 1:10 PM
Study NCT ID:
NCT03950947
Status:
COMPLETED
Last Update Posted:
2019-05-17
First Post:
2019-05-13
Brief Title:
Effect of Permanent Right Internal Mammary Artery Occlusion on Extracardiac Coronary Collateral Supply
Sponsor:
Insel Gruppe AG University Hospital Bern
Organization:
Insel Gruppe AG University Hospital Bern
Study Overview
Official Title:
Effect of Permanent Internal Mammary Artery Occlusion on Extracardiac Coronary Collateral Supply a Randomized Controlled Study
Status:
COMPLETED
Status Verified Date:
2019-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
IMAOR
Brief Summary:
Coronary artery disease and the benefit of bypasses
Despite considerable advances in medicine cardiovascular diseases remain the number one cause of death globally primarily consequence of myocardial infarction MI Coronary collaterals exert a protective effect by providing an alternative source of blood flow to a myocardial territory potentially affected by an acute coronary occlusion Coronary collaterals represent pre-existing inter-arterial anastomoses and as such are the natural counter-part of surgically created bypasses Sufficient coronary collaterals have been shown to confer a significant benefit in terms of overall mortality and cardiovascular events In this regard the concept of augmenting coronary collateral function as an alternative treatment strategy to alter the course of CAD as well as to control symptoms is attractive
Durable promotion of coronary collateral circulation
Before the advent of coronary artery bypass grafting permanent augmentation of coronary collateral supply by a single structural modification has already been attempted Bilateral ligation of the internal mammary arteries IMA was performed in CAD patients to alleviate angina pectoris and electrocardiographic ECG signs of ischemia The prevalent in vivo function of natural internal mammary arteries IMA-to-coronary artery bypasses and their anti-ischemic effect has been recently demonstrated by the investigators research group Levels of collateral function and myocardial ischemia were determined in a prospective open-label clinical trial of permanent IMA device occlusion In this study coronary collateral function has been shown to be augmented in the presence vs the absence of distal permanent ipsilateral IMA occlusion These findings have been corroborated by the observed reduction in ischemia in the intracoronary ECG
After this first step the concept of permanent right IMA occlusion will be now investigated with a randomized sham-controlled clinical trial
Despite considerable advances in medicine cardiovascular diseases remain the number one cause of death globally primarily consequence of myocardial infarction MI Coronary collaterals exert a protective effect by providing an alternative source of blood flow to a myocardial territory potentially affected by an acute coronary occlusion Coronary collaterals represent pre-existing inter-arterial anastomoses and as such are the natural counter-part of surgically created bypasses Sufficient coronary collaterals have been shown to confer a significant benefit in terms of overall mortality and cardiovascular events In this regard the concept of augmenting coronary collateral function as an alternative treatment strategy to alter the course of CAD as well as to control symptoms is attractive
Durable promotion of coronary collateral circulation
Before the advent of coronary artery bypass grafting permanent augmentation of coronary collateral supply by a single structural modification has already been attempted Bilateral ligation of the internal mammary arteries IMA was performed in CAD patients to alleviate angina pectoris and electrocardiographic ECG signs of ischemia The prevalent in vivo function of natural internal mammary arteries IMA-to-coronary artery bypasses and their anti-ischemic effect has been recently demonstrated by the investigators research group Levels of collateral function and myocardial ischemia were determined in a prospective open-label clinical trial of permanent IMA device occlusion In this study coronary collateral function has been shown to be augmented in the presence vs the absence of distal permanent ipsilateral IMA occlusion These findings have been corroborated by the observed reduction in ischemia in the intracoronary ECG
After this first step the concept of permanent right IMA occlusion will be now investigated with a randomized sham-controlled clinical trial
Detailed Description:
Despite considerable advances in medicine cardiovascular diseases remain the number one cause of death globally In industrialized countries coronary artery disease CAD is the leading cause of death consequence of myocardial infarction MI
In patients with acute coronary syndrome percutaneous coronary intervention PCI has been shown to improve outcomes For chronic stable CAD a recent meta-analysis including more than 93000 patients has concluded that there may be evidence for improved survival with new generation drug eluting stents but no other percutaneous revascularization technology compared with medical treatment Conversely a current review of recently published meta-analyses and the detailed analyses of 3 widely quoted individual studies indicate no difference exists among stable CAD patients between PCI and medical therapy regarding nonfatal myocardial infarct or all-cause or cardiovascular mortality A very recently published randomized controlled trial among patients with stable single-vessel CAD the so called ORBITA trial has found that PCI of the stenotic lesion did not prolong exercise time by more than the effect of a sham procedure during the short observation period of 6 weeks
In contrast coronary artery bypass grafting CABG was superior to PCI in patients with diabetes and multivessel CAD CABG significantly reduced rates of death and myocardial infarction compared to PCI but at a higher rate of stroke Furthermore in patients with advanced CAD rates of myocardial infarction were more than 60 lower with CABG compared to PCI
Conceptually the benefit of CABG over PCI is not surprising as PCI targets significant coronary lesions thought to be responsible for causing ischemia However the deleterious effects of atherosclerosis are not typically preceded by significant luminal vascular narrowing The vulnerable plaque eventually becoming the culprit plaque causing myocardial infarction or sudden cardiac death has typically a relatively mild stenosis Furthermore due to being multifocal and widespread plaque vulnerability is not a target for nor amenable to PCI
Conversely artificial - or natural - bypasses exert a protective effect by providing an alternative source of blood flow to a myocardial territory potentially affected by an acute coronary occlusion Coronary collaterals represent pre-existing inter-arterial anastomoses and as such are the natural counter-part of surgically created bypasses Sufficient coronary collaterals have been shown to confer a significant benefit in terms of overall mortality and cardiovascular events
In this regard the concept of augmenting coronary collateral function ie coronary arteriogenesis as an alternative treatment strategy of revascularization to alter the course of CAD is attractive In particular promotion of natural coronary bypasses is an appealing concept for patients with CAD not or not entirely treatable by the conventional coronary revascularization methods of PCI and CABG According to an analysis by Williams et al 142 of 493 patients with chronic stable CAD 29 belonged to the group with incomplete coronary revascularization partial and no revascularization plus the so called no-option group and this group showed reduced survival during the 3-year follow-up period Coronary collateral function promotion from any source could thus contribute to the completeness of myocardial revascularization Incomplete coronary revascularization in chronic CAD has been shown in a very large n35993 patients recently published registry-based study to reduce overall survival according to the number of vessels not treated by PCI and according to the severity of stenoses left untreated Coronary arteriogenesis ie the growth of pre-existing collateral vessels has to occur well in advance of acute atherothrombotic coronary artery occlusion in order to limit infarct size The source of blood supply via natural coronary bypasses collateral arteries to a circulatory area at risk for infarction can be within the coronary circulation but also via extracardiac paths eg via internal mammary arteries IMA also termed internal thoracic arteries Extracardiac coronary artery supply is conceptually related to the term coronary collateral circulation because of its known anatomical structure as arterial anastomoses between eg IMA the pericardium and coronary arterial branches In an editorial Kern and Seto recently commented the concept of Stimulating extracardiac collaterals as follows To be clinically relevant coronary collaterals should be a sustainable and sufficiently large source of myocardial perfusion and reduce ischemia in daily life It is conceivable that improved extracardiac collateral flow has the potential to be exactly that
This study is relevant due to its primary clinical in addition to surrogate marker efficacy testing which has not been performed so far for this new technique of coronary arteriogenesis If proven useful to extend physical exercise time in the context of mitigated angina pectoris a further option of myocardial revascularization for patients with CAD not treatable by PCI or surgical bypass or not rendered asymptomatic by medical therapy would be available The catheter-based technique of IMA device occlusion is simple and safe and if shown efficacious its action would be potentially sustainable due to the durability of occlusion
Preclinical Evidence
The efficacy to augment blood flow via the IMA as naturally existing extracardiac bypasses has been shown in experimental studies in dogs Bilateral IMA ligation has led to an acute average increase in total coronary flow of about 6-10 mlmin
The prevalent in vivo function of natural IMA-to-coronary artery bypasses and their anti-ischemic effect has been recently demonstrated during temporary IMA balloon occlusion by the investigators research group 180 pairs of measurements were performed in 120 patients electively referred for coronary angiography Levels of collateral function and myocardial ischemia were determined during two coronary balloon occlusions the first with the second without distal IMA balloon occlusion
Coronary collateral function as determined by collateral flow index CFI has been consistently increased in the presence vs the absence of distal ipsilateral IMA balloon occlusion These findings have been corroborated by the observed reduction in ischemia as assessed by intracoronary ECG icECG Conversely with distal contralateral IMA occlusion collateral function and ECG signs of ischemia have remained unchanged
Clinical Evidence to Date
Surgical trials in humans on the effect of bilateral IMA ligation on angina pectoris were carried out in the late 1950ies among a total of close to 500 symptomatic CAD patients Transthoracic access to the IMAs was performed under local anesthesia by a small incision between the 2nd and 3rd rib The primary endpoint of the clinical trials was angina pectoris and inconsistently ECG signs of myocardial ischemia While the uncontrolled trials reported favourable results in terms of symptomatic relief of angina pectoris the subsequently performed sham-controlled but very small trials of bilateral ligation showed similar improvement in the sham as in the verum group A major limitation of these studies lies in the rather insensitive endpoints used which preclude conclusions about the efficacy of IMA ligation on extracardiac coronary collateral function
In a prospective open-label proof-of-concept trial the investigators laboratory occluded the right IMA RIMA permanently using a 4-5mm vascular plug in 50 CAD patients As primary study endpoint CFI was obtained during ostial 1-minute balloon occlusion of the untreated right coronary artery RCA at baseline before RIMA device occlusion and 6 weeks later CFI changed from 00710082 at baseline to 01320117 p00001 at follow-up examination The increase in RCA CFI was accompanied by a decrease in signs of myocardial ischemia during the brief coronary occlusion
The acute functional changes observed by the investigators study group in response to temporary distal IMA balloon occlusion as well as the improvement of collateral function in the right coronary artery with permanent distal IMA occlusion support the hypothesis that extracardiac coronary collateral supply can be augmented by this intervention
However the effect of permanent IMA occlusion was never investigated with a randomized clinical trial Consequently our study group conducts a study whereby 100 patients with chronic stable CAD single-blinded for the procedure are randomly allocated 11 to the occlusion or to a sham control group The study endpoints CFI and icECG and clinical signs of myocardial ischemia during RCA occlusion as well as the follow-up duration of 6 weeks are identical in the current and the previous proof-of-concept trial
In patients with acute coronary syndrome percutaneous coronary intervention PCI has been shown to improve outcomes For chronic stable CAD a recent meta-analysis including more than 93000 patients has concluded that there may be evidence for improved survival with new generation drug eluting stents but no other percutaneous revascularization technology compared with medical treatment Conversely a current review of recently published meta-analyses and the detailed analyses of 3 widely quoted individual studies indicate no difference exists among stable CAD patients between PCI and medical therapy regarding nonfatal myocardial infarct or all-cause or cardiovascular mortality A very recently published randomized controlled trial among patients with stable single-vessel CAD the so called ORBITA trial has found that PCI of the stenotic lesion did not prolong exercise time by more than the effect of a sham procedure during the short observation period of 6 weeks
In contrast coronary artery bypass grafting CABG was superior to PCI in patients with diabetes and multivessel CAD CABG significantly reduced rates of death and myocardial infarction compared to PCI but at a higher rate of stroke Furthermore in patients with advanced CAD rates of myocardial infarction were more than 60 lower with CABG compared to PCI
Conceptually the benefit of CABG over PCI is not surprising as PCI targets significant coronary lesions thought to be responsible for causing ischemia However the deleterious effects of atherosclerosis are not typically preceded by significant luminal vascular narrowing The vulnerable plaque eventually becoming the culprit plaque causing myocardial infarction or sudden cardiac death has typically a relatively mild stenosis Furthermore due to being multifocal and widespread plaque vulnerability is not a target for nor amenable to PCI
Conversely artificial - or natural - bypasses exert a protective effect by providing an alternative source of blood flow to a myocardial territory potentially affected by an acute coronary occlusion Coronary collaterals represent pre-existing inter-arterial anastomoses and as such are the natural counter-part of surgically created bypasses Sufficient coronary collaterals have been shown to confer a significant benefit in terms of overall mortality and cardiovascular events
In this regard the concept of augmenting coronary collateral function ie coronary arteriogenesis as an alternative treatment strategy of revascularization to alter the course of CAD is attractive In particular promotion of natural coronary bypasses is an appealing concept for patients with CAD not or not entirely treatable by the conventional coronary revascularization methods of PCI and CABG According to an analysis by Williams et al 142 of 493 patients with chronic stable CAD 29 belonged to the group with incomplete coronary revascularization partial and no revascularization plus the so called no-option group and this group showed reduced survival during the 3-year follow-up period Coronary collateral function promotion from any source could thus contribute to the completeness of myocardial revascularization Incomplete coronary revascularization in chronic CAD has been shown in a very large n35993 patients recently published registry-based study to reduce overall survival according to the number of vessels not treated by PCI and according to the severity of stenoses left untreated Coronary arteriogenesis ie the growth of pre-existing collateral vessels has to occur well in advance of acute atherothrombotic coronary artery occlusion in order to limit infarct size The source of blood supply via natural coronary bypasses collateral arteries to a circulatory area at risk for infarction can be within the coronary circulation but also via extracardiac paths eg via internal mammary arteries IMA also termed internal thoracic arteries Extracardiac coronary artery supply is conceptually related to the term coronary collateral circulation because of its known anatomical structure as arterial anastomoses between eg IMA the pericardium and coronary arterial branches In an editorial Kern and Seto recently commented the concept of Stimulating extracardiac collaterals as follows To be clinically relevant coronary collaterals should be a sustainable and sufficiently large source of myocardial perfusion and reduce ischemia in daily life It is conceivable that improved extracardiac collateral flow has the potential to be exactly that
This study is relevant due to its primary clinical in addition to surrogate marker efficacy testing which has not been performed so far for this new technique of coronary arteriogenesis If proven useful to extend physical exercise time in the context of mitigated angina pectoris a further option of myocardial revascularization for patients with CAD not treatable by PCI or surgical bypass or not rendered asymptomatic by medical therapy would be available The catheter-based technique of IMA device occlusion is simple and safe and if shown efficacious its action would be potentially sustainable due to the durability of occlusion
Preclinical Evidence
The efficacy to augment blood flow via the IMA as naturally existing extracardiac bypasses has been shown in experimental studies in dogs Bilateral IMA ligation has led to an acute average increase in total coronary flow of about 6-10 mlmin
The prevalent in vivo function of natural IMA-to-coronary artery bypasses and their anti-ischemic effect has been recently demonstrated during temporary IMA balloon occlusion by the investigators research group 180 pairs of measurements were performed in 120 patients electively referred for coronary angiography Levels of collateral function and myocardial ischemia were determined during two coronary balloon occlusions the first with the second without distal IMA balloon occlusion
Coronary collateral function as determined by collateral flow index CFI has been consistently increased in the presence vs the absence of distal ipsilateral IMA balloon occlusion These findings have been corroborated by the observed reduction in ischemia as assessed by intracoronary ECG icECG Conversely with distal contralateral IMA occlusion collateral function and ECG signs of ischemia have remained unchanged
Clinical Evidence to Date
Surgical trials in humans on the effect of bilateral IMA ligation on angina pectoris were carried out in the late 1950ies among a total of close to 500 symptomatic CAD patients Transthoracic access to the IMAs was performed under local anesthesia by a small incision between the 2nd and 3rd rib The primary endpoint of the clinical trials was angina pectoris and inconsistently ECG signs of myocardial ischemia While the uncontrolled trials reported favourable results in terms of symptomatic relief of angina pectoris the subsequently performed sham-controlled but very small trials of bilateral ligation showed similar improvement in the sham as in the verum group A major limitation of these studies lies in the rather insensitive endpoints used which preclude conclusions about the efficacy of IMA ligation on extracardiac coronary collateral function
In a prospective open-label proof-of-concept trial the investigators laboratory occluded the right IMA RIMA permanently using a 4-5mm vascular plug in 50 CAD patients As primary study endpoint CFI was obtained during ostial 1-minute balloon occlusion of the untreated right coronary artery RCA at baseline before RIMA device occlusion and 6 weeks later CFI changed from 00710082 at baseline to 01320117 p00001 at follow-up examination The increase in RCA CFI was accompanied by a decrease in signs of myocardial ischemia during the brief coronary occlusion
The acute functional changes observed by the investigators study group in response to temporary distal IMA balloon occlusion as well as the improvement of collateral function in the right coronary artery with permanent distal IMA occlusion support the hypothesis that extracardiac coronary collateral supply can be augmented by this intervention
However the effect of permanent IMA occlusion was never investigated with a randomized clinical trial Consequently our study group conducts a study whereby 100 patients with chronic stable CAD single-blinded for the procedure are randomly allocated 11 to the occlusion or to a sham control group The study endpoints CFI and icECG and clinical signs of myocardial ischemia during RCA occlusion as well as the follow-up duration of 6 weeks are identical in the current and the previous proof-of-concept trial
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None