Ignite Creation Date:
2024-05-05 @ 4:56 PM
Last Modification Date:
2024-10-26 @ 9:26 AM
Study NCT ID:
NCT00346476
Status:
COMPLETED
Last Update Posted:
2011-02-11
First Post:
2006-06-28
Brief Title:
Characteristics and Prevalence of Tuberculosis and HIV in Masiphumelele Township Cape Town South Africa
Sponsor:
CIPRA SA
Organization:
CIPRA SA
Study Overview
Official Title:
A Study of the Effects of Antiretroviral Therapy on Rates and Transmission of Tuberculosis
Status:
COMPLETED
Status Verified Date:
2011-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to determine the number of people infected with tuberculosis TB in the Masiphumelele Township of Cape Town South Africa a community with high rates of TB and HIV This study will also examine the genetics of TB and the relationships among active TB infection new HIV infections and HIV disease progression
Detailed Description:
TB is the most common opportunistic infection and the single most common cause of death in HIV infected people in Africa today Latent TB infection has been known to revert to active TB following new infection in HIV infected people also TB has been shown to accelerate the progression of HIV disease These epidemiologic relationships between TB and HIV and the high prevalence of these diseases in sub-Saharan Africa make studying TB and HIV infected populations in this region of the world important The Masiphumelele Township of Cape Town South Africa with its high rates of TB and HIV is representative of many poor communities in Africa The purpose of this study is to observe people from the Masiphumelele Township over a 5-year period to assess the prevalence of TB and HIV infections in a random sample of people and the clinical and genetic characteristics of active TB infection
This study has two parts a random cross-sectional survey and a clinical and genetic assessment of TB patients Participants in the random survey will only be involved with the study for a maximum of 2 days The purpose of the first part of the study is to compare the prevalence of active TB and the prevalence of HIV infection in a random sample of people from the Masiphumelele Township In this part of the study children and adults will be randomly selected from the township population to determine the prevalence of active TB and the prevalence of HIV infection in this group of people Fieldworkers will identify eligible participants in the township and will ask them to visit the clinic that day or the next At the clinic participants will be asked to complete a demographics and TB history questionnaire and provide a saliva sample for anonymous HIV testing A sputum sample will be collected from each participant with a nebulizer each participant will also be given a sputum sample bottle and will be asked to collect an early morning sputum sample on the next day that will be returned to the clinic
The second part of the study will enroll TB patients Participants in this part of this study will be followed for the course of their TB treatment for at least 6 months The purpose of the second part of the study is to assess changes through time of the clustering and transmission of TB among HIV infected and uninfected people in the Masiphumelele Township This assessment will include examining the diversity of TB strains in this population and determining the relationship between recurrent cases of TB and HIV infection All sputum samples indicating TB infections that were previously collected from participants will undergo genetic testing by restriction fragment length polymorphism RFLP analysis Participants will be asked to complete a demographics and TB history questionnaire and provide a saliva sample for anonymous HIV testing Participants will also be interviewed about treatment they have received for TB their responses to this treatment and whether they are currently on highly active antiretroviral therapy HAART for the treatment of HIV infection
Participants who are found to be infected with TB during the first part of the study will be offered TB treatment through the clinic and will be invited to participate in the second part of this study Participants who are found to be infected with HIV during the study will be referred to further treatment and evaluation
This study has two parts a random cross-sectional survey and a clinical and genetic assessment of TB patients Participants in the random survey will only be involved with the study for a maximum of 2 days The purpose of the first part of the study is to compare the prevalence of active TB and the prevalence of HIV infection in a random sample of people from the Masiphumelele Township In this part of the study children and adults will be randomly selected from the township population to determine the prevalence of active TB and the prevalence of HIV infection in this group of people Fieldworkers will identify eligible participants in the township and will ask them to visit the clinic that day or the next At the clinic participants will be asked to complete a demographics and TB history questionnaire and provide a saliva sample for anonymous HIV testing A sputum sample will be collected from each participant with a nebulizer each participant will also be given a sputum sample bottle and will be asked to collect an early morning sputum sample on the next day that will be returned to the clinic
The second part of the study will enroll TB patients Participants in this part of this study will be followed for the course of their TB treatment for at least 6 months The purpose of the second part of the study is to assess changes through time of the clustering and transmission of TB among HIV infected and uninfected people in the Masiphumelele Township This assessment will include examining the diversity of TB strains in this population and determining the relationship between recurrent cases of TB and HIV infection All sputum samples indicating TB infections that were previously collected from participants will undergo genetic testing by restriction fragment length polymorphism RFLP analysis Participants will be asked to complete a demographics and TB history questionnaire and provide a saliva sample for anonymous HIV testing Participants will also be interviewed about treatment they have received for TB their responses to this treatment and whether they are currently on highly active antiretroviral therapy HAART for the treatment of HIV infection
Participants who are found to be infected with TB during the first part of the study will be offered TB treatment through the clinic and will be invited to participate in the second part of this study Participants who are found to be infected with HIV during the study will be referred to further treatment and evaluation
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| U19AI053217 | NIH | None | httpsreporternihgovquickSearchU19AI053217 |