Ignite Creation Date:
2024-05-06 @ 1:09 PM
Last Modification Date:
2024-10-26 @ 1:10 PM
Study NCT ID:
NCT03948997
Status:
COMPLETED
Last Update Posted:
2021-03-11
First Post:
2019-05-10
Brief Title:
The Role of Angiogenesis-related Pathways in the Development of Port Wine Stains
Sponsor:
xjpfW
Organization:
Xijing Hospital
Study Overview
Official Title:
The Role of Angiogenesis-related Pathways in the Development of Refractory Port Wine Stains
Status:
COMPLETED
Status Verified Date:
2021-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
1 Port wine stain PWS is a congenital progressive vascular malformation of human skin involving the superficial vascular plexus that occurs in estimated 3-5 children per 1000 live births In childhood PWS are flat red macules but lesions tend to darken progressively to purple and by middle age often become raised as a result of the development of vascular nodules Because most malformations occur on the face PWS is a clinically significant problem in the majority of patients
2 The late-stage cobblestoning appearance of PWS subjects is comprised by not only pronounced vascular ectasia with proliferation of thin andor thick-walled vessels and their stroma but also numerous epithelial neural and mesenchymal hamartomatous abnormalities Despite these histologic observations the specific mechanisms involved in PWS nodular formation remains unclear
3 In one nodular PWS subject we found that phosphatidylinositol 3-kinases PI3Kprotein kinase B AKT and phosphoinositide phospholipase C g subunit PLC-g were activated in both hypertrophic areas and nodules within the lesion These observations led us to hypothesize that the PI3K pathway may play an important role in nodular formation
2 The late-stage cobblestoning appearance of PWS subjects is comprised by not only pronounced vascular ectasia with proliferation of thin andor thick-walled vessels and their stroma but also numerous epithelial neural and mesenchymal hamartomatous abnormalities Despite these histologic observations the specific mechanisms involved in PWS nodular formation remains unclear
3 In one nodular PWS subject we found that phosphatidylinositol 3-kinases PI3Kprotein kinase B AKT and phosphoinositide phospholipase C g subunit PLC-g were activated in both hypertrophic areas and nodules within the lesion These observations led us to hypothesize that the PI3K pathway may play an important role in nodular formation
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None