Ignite Creation Date:
2024-05-06 @ 1:08 PM
Last Modification Date:
2024-10-26 @ 1:09 PM
Study NCT ID:
NCT03943459
Status:
UNKNOWN
Last Update Posted:
2019-10-04
First Post:
2019-05-07
Brief Title:
Sirtuin-1 and Advanced Glycation End-products in Postmenopausal Women With Coronary Disease
Sponsor:
InCor Heart Institute
Organization:
InCor Heart Institute
Study Overview
Official Title:
Serum Concentration and Gene Expression of Sirtuin-1 and Advanced Glycation End-products in Postmenopausal Women With Atherosclerotic Coronary Disease After Administration of Atorvastatin and Supplementation With Quercetin Randomized Trial
Status:
UNKNOWN
Status Verified Date:
2019-10
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Higher consumption of fruits and vegetables promote greater availability of phenolic compounds and these compounds were associated with vascular health Quercetin a phenolic compound is the most abundant natural antioxidant belonging to the group of flavonoids Quercetin improved lipoprotein metabolism had antioxidant capacity produced vasodilating substances in the vascular endothelium and reduced platelet aggregability Likewise statins are medications known to reduce cardiovascular events in women with coronary disease by reducing serum LDL-cholesterol Therefore a number of metabolic pathways are responsible for vascular health The serum concentration and gene expression of sirtuin 1 Sirt1 and RAGE soluble sRAGE are directly associated with vascular protection This study will analyse the influence of atorvastatin and quercetin on serum concentrations and gene expression of Sirt1 and sRAGE in postmenopausal women with stable coronary artery disease
Detailed Description:
Higher consumption of fruits and vegetables promote greater availability of phenolic compounds and these compounds were associated with vascular health Quercetin a phenolic compound is the most abundant natural antioxidant belonging to the group of flavonoids Quercetin improved lipoprotein metabolism had antioxidant capacity produced vasodilating substances in the vascular endothelium and reduced platelet aggregability Likewise statins are medications known to reduce cardiovascular events in women with coronary artery disease CAD by reducing serum LDL-cholesterol Therefore a number of metabolic pathways are responsible for vascular health The serum concentration and gene expression of sirtuin 1 Sirt1 and RAGE soluble sRAGE are directly associated with vascular protection This study will analyse the influence of atorvastatin and quercetin on serum concentrations and gene expression of Sirt1 and sRAGE in postmenopausal women with stable coronary artery disease and also the correlation between the changes in serum concentration of Sirt1 and sRAGE and the changes in lipid profile inflammatory biomarkers and sex hormones in response to these drugs This is a 60-day randomized double blind placebo-controlled study in 60 postmenopausal women with CAD divided into three groups with 20 women each Group 1 - Quercetin 500 mg day Group 2 - atorvastatin 80 mg day Group 3 - control
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None