Ignite Creation Date:
2024-05-05 @ 4:55 PM
Last Modification Date:
2024-10-26 @ 9:25 AM
Study NCT ID:
NCT00341770
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
2006-06-19
Brief Title:
Assessment of Sympathetic Nervous System Activity by Microneurography Recording Technique
Sponsor:
National Institute of Diabetes and Digestive and Kidney Diseases NIDDK
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Assessment of Sympathetic Nervous System Activity by Microneurography Recording Technique
Status:
COMPLETED
Status Verified Date:
2010-11-23
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Obesity is the consequence of an imbalance between energy intake and energy expenditure Recent studies have suggested that the sympathetic nervous system SNS may be an important determinant of the rate of energy expenditure in man Indirect assessments of the sympathetic nervous activity in Pima Indians have recently shown impaired SNS-mediated energy expenditure in this obesity-prone population We plan to perform direct microelectrode nerve recording of the sympathetic innervation of the lower leg to directly assess SNS activity and examine its potential role in the regulation of metabolic rate and the development of obesity Measurements will be performed in the basal state in response to glucose feeding 75 g OGTT and in response to glucoseinsulin infusion These studies also will help to disassociate the effect of insulin and glucose on the stimulation of SNS activity Energy expenditure measurements will be performed over 24 hours in the respiratory chamber and for 2 12 hours before and during the euglycemic clamp Results also will be used to determine possible racial differences between Pimas and Caucasians since the risk for obesity is markedly different in these populations To exclude the possibility of a normal SNS activity but with peripheral resistance to the action of norepineprine we will perform adrenergic stimulation by isoproterenol to measure peripheral adrenergic sensitivity
Detailed Description:
Obesity is the consequence of an imbalance between energy intake and energy expenditure Recent studies have suggested that the sympathetic nervous system SNS may be an important determinant of the rate of energy expenditure in man Indirect assessments of the sympathetic nervous activity in Pima Indians have recently shown impaired SNS-mediated energy expenditure in this obesity-prone population We plan to perform direct microelectrode nerve recording of the sympathetic innervation of the lower leg to directly assess SNS activity and examine its potential role in the regulation of metabolic rate and the development of obesity Measurements will be performed in the basal state in response to glucose feeding 75 g OGTT in response to a standard meal and in response to glucoseinsulin infusion These studies also will help to disassociate the effect of insulin and glucose on the stimulation of SNS activity The association between postprandial changes in SNS activity and subjective ratings of hunger and fullness also will be studied Energy expenditure measurements will be performed over 24 hours in the respiratory chamber and for 2 12 hours before and during the euglycemic clamp Results also will be used to determine possible racial differences between Pimas and Caucasians since the risk for obesity is markedly different in these populations To exclude the possibility of a normal SNS activity but with peripheral resistance to the action of norepineprine we will perform adrenergic stimulation by isoproterenol to measure peripheral adrenergic sensitivity
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| OH91-DK-0107 | None | None | None |