Ignite Creation Date:
2024-05-05 @ 4:55 PM
Last Modification Date:
2024-10-26 @ 9:25 AM
Study NCT ID:
NCT00342147
Status:
COMPLETED
Last Update Posted:
2020-12-11
First Post:
2006-06-19
Brief Title:
Family Study of Head and Neck Cancers in Taiwan
Sponsor:
National Cancer Institute NCI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Family Study of Head and Neck Cancers in Taiwan
Status:
COMPLETED
Status Verified Date:
2020-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Nasopharyngeal carcinoma is a rare tumor among Caucasians which occurs with high incidence among individuals of Chinese descent The disease is believed to have a multifactorial etiology with genetic viral and other environmental factors being involved Little is known however about the genetic component of this disease
We have recently completed subject recruitment for a case-control study of NPC in Taiwan Using information obtained from the NPC cases recruited into this NCI-sponsored case-control study as well as from a parallel cross-sectional study conducted by our Taiwanese collaborators we have been able to identify 120-150 families with multiple family members affected with NPC
The purpose of the study described herein is to determine the role of inherited genetic factors in the etiology of NPC and to examine the effect of these genetic susceptibility factors on risk associated with environmental exposures
Families will initially be contacted via the proband who previously participated in our case-control and cross-sectional studies Subsequently informative family members will be asked to visit the study clinic to participate in the study A family history questionnaire will be administered to the proband from each of the families selected for study In addition a risk factor questionnaire will be administered to all participating family members and 30-40 ml of blood and an oral sample will be obtained from each study participant Additional study components include medical record review to verify the diagnosis of NPC retrieval of tumor tissue blocks as a source of DNA for study and clinical exams on a sample of unaffected individuals to exclude the possibility of prevalent undetected disease among family members
Oral and laryngeal cancer families will also be recruited in a manner similar to that described for NPC families in an attempt to elucidate genetic factors linked to the development of these two cancers
We have recently completed subject recruitment for a case-control study of NPC in Taiwan Using information obtained from the NPC cases recruited into this NCI-sponsored case-control study as well as from a parallel cross-sectional study conducted by our Taiwanese collaborators we have been able to identify 120-150 families with multiple family members affected with NPC
The purpose of the study described herein is to determine the role of inherited genetic factors in the etiology of NPC and to examine the effect of these genetic susceptibility factors on risk associated with environmental exposures
Families will initially be contacted via the proband who previously participated in our case-control and cross-sectional studies Subsequently informative family members will be asked to visit the study clinic to participate in the study A family history questionnaire will be administered to the proband from each of the families selected for study In addition a risk factor questionnaire will be administered to all participating family members and 30-40 ml of blood and an oral sample will be obtained from each study participant Additional study components include medical record review to verify the diagnosis of NPC retrieval of tumor tissue blocks as a source of DNA for study and clinical exams on a sample of unaffected individuals to exclude the possibility of prevalent undetected disease among family members
Oral and laryngeal cancer families will also be recruited in a manner similar to that described for NPC families in an attempt to elucidate genetic factors linked to the development of these two cancers
Detailed Description:
Nasopharyngeal carcinoma is a rare tumor among Caucasians that occurs with high incidence among individuals of Chinese descent The disease is believed to have a multifactorial etiology with genetic viral and other environmental factors being involved Little is known however about the genetic component of this disease
We previously completed a case-control study of NPC in Taiwan Using information obtained from the NPC cases recruited into this NCI-sponsored case-control study and parallel sources we have been able to identify 250 families with multiple family members affected with NPC
The purpose of the study described herein is to determine the role of inherited genetic factors in the etiology of NPC and to examine the effect of these genetic susceptibility factors on risk associated with environmental exposures
Families will initially be contacted via an affected proband Subsequently informative family members will be asked to visit the study clinic to participate in the study A family history questionnaire will be administered to the proband and other affected family members from each of the families selected for study In addition a risk factor questionnaire will be administered to all participating family members and 30-40 ml of blood and an oral sample will be obtained from each study participant Additional study components include medical record review to verify the diagnosis of NPC retrieval of tumor tissue blocks as a source of DNA for study and clinical exams on a sample of unaffected individuals to exclude the possibility of prevalent undetected disease among family members
Oral and laryngeal cancer families will also be recruited in a manner similar to that described for NPC families in an attempt to elucidate genetic factors linked to the development of these two cancers
We previously completed a case-control study of NPC in Taiwan Using information obtained from the NPC cases recruited into this NCI-sponsored case-control study and parallel sources we have been able to identify 250 families with multiple family members affected with NPC
The purpose of the study described herein is to determine the role of inherited genetic factors in the etiology of NPC and to examine the effect of these genetic susceptibility factors on risk associated with environmental exposures
Families will initially be contacted via an affected proband Subsequently informative family members will be asked to visit the study clinic to participate in the study A family history questionnaire will be administered to the proband and other affected family members from each of the families selected for study In addition a risk factor questionnaire will be administered to all participating family members and 30-40 ml of blood and an oral sample will be obtained from each study participant Additional study components include medical record review to verify the diagnosis of NPC retrieval of tumor tissue blocks as a source of DNA for study and clinical exams on a sample of unaffected individuals to exclude the possibility of prevalent undetected disease among family members
Oral and laryngeal cancer families will also be recruited in a manner similar to that described for NPC families in an attempt to elucidate genetic factors linked to the development of these two cancers
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| OH95-C-N046 | None | None | None |