Ignite Creation Date:
2024-05-05 @ 4:55 PM
Last Modification Date:
2024-10-26 @ 9:25 AM
Study NCT ID:
NCT00344292
Status:
COMPLETED
Last Update Posted:
2017-11-08
First Post:
2006-06-23
Brief Title:
Understanding the Genetic and Hereditary Basis of Atherosclerosis
Sponsor:
Wake Forest University Health Sciences
Organization:
Wake Forest University Health Sciences
Study Overview
Official Title:
SNPs and Extent of Atherosclerosis SEA Study
Status:
COMPLETED
Status Verified Date:
2017-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Atherosclerosis is a condition that occurs when fatty deposits build up along the inner walls of arteries New strategies are needed to prevent and treat atherosclerosis The purpose of this study is to analyze the DNA of participants in two ongoing studies to identify genetic variations responsible for the development of atherosclerosis
Detailed Description:
Atherosclerosis is a condition in which deposits of fat cholesterol and other substances build up along the inner walls of arteries these deposits are known as plaque As plaque builds up it increases the risk of blood clots heart attack and stroke Research has shown that the risk of developing atherosclerosis can be influenced by heredity However researchers have been unable to identify the specific genes associated with this risk Single nucleotide polymorphisms SNPs are small genetic variations that can occur within an individuals DNA In this study researchers will analyze the DNA of many individuals for differences in SNP patterns The goal of the study is to determine which SNP patterns are associated with the development of atherosclerosis The data from this study may lead to new strategies for early identification of high risk individuals who may benefit from aggressive treatment to prevent the development of atherosclerosis
This study will not recruit any new participants DNA will be collected and analyzed from participants in two existing studies-the Pathobiological Determinants of Atherosclerosis in Youth PDAY study and the Multi-Ethnic Study of Atherosclerosis MESA DNA from the PDAY participants will be obtained from liver samples gathered during an autopsy following the participants deaths DNA from the MESA participants will be obtained from blood collected during routine study visits There will be no additional study visits for participants and all DNA samples and study information will be kept confidential Genetic testing will be performed to determine the association between SNPs and subclinical atherosclerosis which is a form of the condition prior to the onset of symptoms The study will evaluate specific variations in SNPs and subclinical disease among different ethnic groups which may help to explain why certain ethnic groups have higher rates of atherosclerosis The study will also examine the association between SNPs and other indicators of subclinical and clinical atherosclerosis including the thickness of arteries heart calcium levels and blood pressure levels
This study will not recruit any new participants DNA will be collected and analyzed from participants in two existing studies-the Pathobiological Determinants of Atherosclerosis in Youth PDAY study and the Multi-Ethnic Study of Atherosclerosis MESA DNA from the PDAY participants will be obtained from liver samples gathered during an autopsy following the participants deaths DNA from the MESA participants will be obtained from blood collected during routine study visits There will be no additional study visits for participants and all DNA samples and study information will be kept confidential Genetic testing will be performed to determine the association between SNPs and subclinical atherosclerosis which is a form of the condition prior to the onset of symptoms The study will evaluate specific variations in SNPs and subclinical disease among different ethnic groups which may help to explain why certain ethnic groups have higher rates of atherosclerosis The study will also examine the association between SNPs and other indicators of subclinical and clinical atherosclerosis including the thickness of arteries heart calcium levels and blood pressure levels
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01 HL080443-01A1 | US NIH GrantContract | None | httpsreporternihgovquickSearchU01HL080443-01A1 |
| U01HL080443-01A1 | NIH | None | None |