Ignite Creation Date:
2024-05-06 @ 1:02 PM
Last Modification Date:
2024-10-26 @ 1:07 PM
Study NCT ID:
NCT03912766
Status:
COMPLETED
Last Update Posted:
2019-04-11
First Post:
2019-04-05
Brief Title:
Serum Copeptin as a Predictor of the Risk of Hyponatremia After Transurethral Prostatectomy
Sponsor:
Medical University of Lodz
Organization:
Medical University of Lodz
Study Overview
Official Title:
Serum Copeptin as a Predictor of the Risk of Hyponatremia After Transurethral Prostatectomy
Status:
COMPLETED
Status Verified Date:
2019-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Hyponatremic hypovolemia is a frequent complication of transurethral resection of the prostate gland TURP Copeptin has been established as is a surrogate marker of vasopressin and is measured useful for thea clinical assessment of various sodium and water disturbances The aim of our the study was to assess the utility of serum concentration of copeptin CPP and brain natriuretic peptide NT-proBNP for the prediction of postoperative alterations of serum sodium concentration Study population comprised 43 patients with benign prostatic hyperplasia BPH undergoing transurethral resection of the prostate gland In a forward stepwise multiple regression only serum copeptin before the surgery and the duration of TURP significantly explained the variation of sodium concentration for 12 hours from the start of the surgery Serum NT-proBNP before the surgery did not predict hyponatremia 12 hours after TURPConclusion Serum copeptin before TURP surgery but not NT-proBNP may be a clinically useful marker of a decrease of serum sodium after TURP surgery
Detailed Description:
IntroductionHyponatremic hypovolemia is a frequent complication of transurethral resection of the prostate gland TURP Copeptin has been established as is a surrogate marker of vasopressin and is measured useful for thea clinical assessment of various sodium and water disturbances The aim of our the study was to assess the utility of serum concentration of copeptin CPP and brain natriuretic peptide NT-proBNP for the prediction of postoperative alterations of serum sodium concentration
Methods Study population comprised 43 patients with benign prostatic hyperplasia BPH undergoing transurethral resection of the prostate gland TURP Serum sodium and copeptin CPP were measured before the procedure and 12 hours after its completion and sSerum NT-proBNP was assessment at baseline Total amount of fluids and sodium administered intravenously and to flush the bladder during TURP was calculated in each patient Receiver operator characteristics ROC curve analysis was used to determine the value of of copeptin CPP and NT-proBNP for that could prediction of the decrease of serum sodium after TURP
Methods Study population comprised 43 patients with benign prostatic hyperplasia BPH undergoing transurethral resection of the prostate gland TURP Serum sodium and copeptin CPP were measured before the procedure and 12 hours after its completion and sSerum NT-proBNP was assessment at baseline Total amount of fluids and sodium administered intravenously and to flush the bladder during TURP was calculated in each patient Receiver operator characteristics ROC curve analysis was used to determine the value of of copeptin CPP and NT-proBNP for that could prediction of the decrease of serum sodium after TURP
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None