Ignite Creation Date:
2024-05-05 @ 4:55 PM
Last Modification Date:
2024-10-26 @ 9:25 AM
Study NCT ID:
NCT00341861
Status:
COMPLETED
Last Update Posted:
2020-10-22
First Post:
2006-06-19
Brief Title:
Interdisciplinary Case-Control Study of Bladder Cancer in Spain
Sponsor:
National Cancer Institute NCI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Interdisciplinary Case-Control Study of Bladder Cancer in Spain
Status:
COMPLETED
Status Verified Date:
2020-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The incidence rate of bladder cancer in the Barcelona area of Spain is almost identical to that of the US Cigarette smoking has been identified as the most significant risk factor for bladder cancer followed by occupational exposures to chemicals such as aromatic amines and their derivatives diesel exhaust oil mist pesticides and polynuclear aromatic hydrocarbons A variety of non-occupational exposures have been suggested as potential risk factors as well including smoking black vs blond tobacco dietary factors certain medications and medical conditions chlorination by-products in drinking water and fluid intake Various genetic polymorphisms also appear to affect bladder cancer risk Research is needed to further explore hypotheses generated by previous etiologic studies of bladder cancer An on-going study of bladder cancer survival by the Institut Municipal dInvestigacio Medica in Spain provides an excellent opportunity for NCI to perform such research NCI will build upon the ongoing study by funding an interdisciplinary case-control component to evaluate bladder cancer risk in relation to various external factors eg occupational and environmental exposure and host factors eg genetic susceptibility markers and early effect markers This hospital-based case-control study will involve personal interviews using a state-of-the-art computer assisted technique and collection of blood and toenail samples from participants
Detailed Description:
The incidence rate of bladder cancer in the Barcelona area of Spain is almost identical to that of the US Cigarette smoking has been identified as the most significant risk factor for bladder cancer followed by occupational exposures to chemicals such as aromatic amines and their derivatives diesel exhaust oil mist pesticides and polynuclear aromatic hydrocarbons A variety of non-occupational exposures have been suggested as potential risk factors as well including smoking black vs blond tobacco dietary factors certain medications and medical conditions chlorination by-products in drinking water and fluid intake Various genetic polymorphisms also appear to affect bladder cancer risk Research is needed to further explore hypotheses generated by previous etiologic studies of bladder cancer An ongoing study of bladder cancer survival by the Institut Municipal dInvestigacio Medica in Spain provides an excellent opportunity for NCI to perform such research NCI will build upon the ongoing study by funding an interdisciplinary case-control component to evaluate bladder cancer risk in relation to various external factors eg occupational and environmental exposure and host factors eg genetic susceptibility marker and early effect markers This hospital-based case-control study will involve personal interviews using a state-of-the-art computer-assisted technique and collection of blood and toenail samples from participants
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| OH99-C-N038 | None | None | None |