Ignite Creation Date:
2024-05-05 @ 4:55 PM
Last Modification Date:
2024-10-26 @ 9:25 AM
Study NCT ID:
NCT00340509
Status:
COMPLETED
Last Update Posted:
2019-12-16
First Post:
2006-06-19
Brief Title:
A Genome-Wide Scan For Quantitative Trait Loci of Serum Bilirubin - A Framingham Study
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
A Genome-Wide Scan For Quantitative Trait Loci of Serum Bilirubin - A Framingham Study
Status:
COMPLETED
Status Verified Date:
2013-07-23
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Studies have shown that there is a significant association between serum bilirubin concentrations and risk of coronary artery disease CAD So far no linkage analysis in humans between serum bilirubin and DNA markers has been reported The purpose of this protocol is to identify chromosome regions that contain quantitative trait loci QTL involved in serum bilirubin metabolism and bilirubin concentration In the Framingham Study a 10cM genome scan about 400 markers has been conducted in more than three hundred families Serum bilirubin was measured in the first and second exams of the Framingham Offspring These data provide us the opportunity to undertake linkage analyses to map QTL of serum bilirubin
Detailed Description:
Many studies showed that there is a significant relationship between serum bilirubin levels and risk of coronary artery disease CAD We carried out a genome-wide scan for quantitative trait loci of serum bilirubin through the 330 extended Framingham families and found significant evidence of linkage of serum bilirubin to chromosome 2q telomere where an important candidate gene Uridine diphosphate glycosyltransferase 1 gene UGT1A1 resides The purposes of this protocol are to confirm linkage between serum bilirubin and UGT1A1 mathematical modeling and association studies between the genotypes of UGT1A1 and CAD
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 02-H-N016 | None | None | None |