Ignite Creation Date:
2024-05-05 @ 4:55 PM
Last Modification Date:
2024-10-26 @ 9:25 AM
Study NCT ID:
NCT00341965
Status:
COMPLETED
Last Update Posted:
2019-09-03
First Post:
2006-06-19
Brief Title:
Pesticide Exposure and Health Status in North Carolina African American Male Farmers and Farm Workers
Sponsor:
National Institute of Environmental Health Sciences NIEHS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Pesticide Exposure and Health Status in NC African American Male Farmers and Farm Workers
Status:
COMPLETED
Status Verified Date:
2013-11-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
We propose to conduct a study to increase our understanding of farming practices and of the potential for previous exposure to DDT in North Carolina African American male agricultural workers a group especially likely to have had high DDT exposure Because of potentially widespread DDT exposure from agricultural activities African American farmers and farm workers may be uniquely at risk for any associated health effects However little is known about levels of pesticide exposure in African American farming populations Three hundred and eighty-nine African American men who are current or former farmers or farm workers will be asked to participate in the study These men are members of the Supplemental Minority Cohort of the NCINIEHSEPA Agricultural Health Study AHS The AHS is a prospective study of the potential health effects associated with agricultural exposures Men in the supplemental cohort were recruited in 1996 At that time they completed an enrollment questionnaire that focused on lifetime agricultural exposures demographics lifestyle factors and health In this new study a follow-up questionnaire will be administered by telephone by a trained interviewer to all men Following the interview the participant will be asked to donate a blood specimen to have anthropometric indices eg height weight waist and hip circumference etc measured and to have a top- and side view Polaroid photograph of their head taken during one visit to a central community location such as the local church or health clinic We will quantitatively document serum pp-DDE levels correlate these with self-reported farming activities and DDT exposure and describe the health status of these men We will also correlate serum pp-DDE levels and androgen concentrations since pp-DDE is thought to be a potent androgen receptor antagonist This exploration of the potential link between levels is important because the demonstration of any subclinical physiological effects of pp-DDE would increase the plausibility of a wide range of health effects that have been postulated to be associated with the endogenous endocrine environment and the so-called endocrine disrupters In addition we will evaluate the relationship between several important physiological parameters which can be easily and accurately measured in serum and physical characteristics including hair patterning and distribution of body fat in these African American men
Detailed Description:
We propose to conduct a study to increase our understanding of farming practices and of the potential for previous exposure to DDT in North Carolina African American male agricultural workers a group especially likely to have had high DDT exposure Because of potentially widespread DDT exposure from agricultural activities African American farmers and farm workers may be uniquely at risk for any associated health effects However little is known about levels of pesticide exposure in African American farming populations Three hundred and eighty-nine African American men who are current or former farmers or farm workers will be asked to participate in the study These men are members of the Supplemental Minority Cohort of the NCINIEHSEPA Agricultural Health Study AHS The AHS is a prospective study of the potential health effects associated with agricultural exposures Men in the supplemental cohort were recruited in 1996 At that time they completed an enrollment questionnaire that focused on lifetime agricultural exposures demographics lifestyle factors and health In this new study a follow-up questionnaire will be administered by telephone by a trained interviewer to all men Following the interview the participant will be asked to donate a blood specimen to have anthropometric indices eg height weight waist and hip circumference etc measured and to have a top- and side view Polaroid photograph of their head taken during one visit to a central community location such as the local church or health clinic We will quantitatively document serum pp-DDE levels correlate these with self-reported farming activities and DDT exposure and describe the health status of these men We will also correlate serum pp-DDE levels and androgen concentrations since pp-DDE is thought to be a potent androgen receptor antagonist This exploration of the potential link between levels is important because the demonstration of any subclinical physiological effects of pp-DDE would increase the plausibility of a wide range of health effects that have been postulated to be associated with the endogenous endocrine environment and the so-called endocrine disrupters In addition we will evaluate the relationship between several important physiological parameters which can be easily and accurately measured in serum and physical characteristics including hair patterning and distribution of body fat in these African American men
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| OH99-E-N006 | None | None | None |