Ignite Creation Date:
2024-05-06 @ 1:01 PM
Last Modification Date:
2024-10-26 @ 1:07 PM
Study NCT ID:
NCT03902392
Status:
COMPLETED
Last Update Posted:
2020-01-02
First Post:
2019-02-14
Brief Title:
Red Grape Polyphenol Oral Administration to Women Affected by Nickel-mediated Allergic Contact Dermatitis
Sponsor:
University of Bari
Organization:
University of Bari
Study Overview
Official Title:
Oral Human Administration of Red Grape Polyphenol in Nickel-mediated Allergic Contact Dermatitis an in Vitro Study
Status:
COMPLETED
Status Verified Date:
2019-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
Grapolyphen
Brief Summary:
Nickel Ni-mediated allergic contact dermatitis ACD is a very common disease worldwide Our previous findings demonstrated that in vitro supplementation of polyphenols extracted from seeds of red grape Nero di Troia cultivar to peripheral lymphomonocytes from Ni-mediated ACD patients could reduce release of T helper h1 interferon IFN- and Th2 interleukin IL-4 cytokines on the one hand On the other hand IL-10 an anti-inflammatory cytokine levels increased with a reduction of IL-17 an inflammatory cytokine Also levels of nitric oxide NO decreased in response to polyphenol pretreatment
Detailed Description:
Nickel Ni is a transitional metal largely distributed in the environment whose continuous exposure is able to provoke local and systemic allergic contact dermatitis ACD Ni-mediated ACD is characterized by loss of epidermal integrity urticariaangioedema flares and itching whose extent depends on many variables such as genetic time of sensitization and environmental exposureThe aim of the present research is to verify whether the oral administration of polyphenols NATUR-OX to patients with Ni-mediated ACD is able to modify immune parameters
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None