Ignite Creation Date:
2024-05-05 @ 4:55 PM
Last Modification Date:
2024-10-26 @ 9:25 AM
Study NCT ID:
NCT00342173
Status:
TERMINATED
Last Update Posted:
2020-03-16
First Post:
2006-06-19
Brief Title:
Costa Rican Natural History Study of HPV and Cervical Neoplasia
Sponsor:
National Cancer Institute NCI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Costa Rican Natural History Study of HPV and Cervical Neoplasia
Status:
TERMINATED
Status Verified Date:
2020-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
classified by the IRB as non human subjects research
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
A population-based study was initiated in Costa Rica in June 1993 to investigate the natural history of human papillomaviruses HPV and cervical neoplasia Over a period of 18 months ending in December 1994 10080 women were recruited into our study after informed consent was obtained At the initial recruitment visit all women were administered a brief risk factor questionnaire had 15ml of blood collected and if sexually active were given a pelvic examination At the time of the pelvic examination a Pap smear was collected as were additional cervical cells which were then used for additional monolayer smears ThinPrep and for human papillomavirus and other testing Pictures of the cervix known as cervigrams were also taken as a third screening test Based on these screening tests women were referred to colposcopy at which time a more detailed risk factor questionnaire was administered additional cervical cells and blood 15ml were collected and histological specimens were obtained if indicated by the colposcopy Women diagnosed with a high-grade cervical lesion HSIL or cervical cancer were treated by Social Security Administration clinicians using standard local protocols
Women without evidence of HSIL or cancer at enrollment comprise the group of subjects who have been followed as part of our longitudinal study Three distinct groups of women of approximately equal size about 3000 women each exist within our longitudinal cohort The first group consists of women who at enrollment had evidence of low-grade cervical lesions LSIL or equivocal lesions and a sample of the remaining cohort members This group is being followed actively at 6-12 month intervals through their seventh anniversary in the cohort The second group consists of women who were cytologically normal at enrollment but randomly selected for active follow-up This second group will be seen once after enrollment at their fifth anniversary in the cohort Women in this group with evidence of LSIL at the fifth anniversary visit will be added to the first group described above and followed at 6-month intervals The final group consists of the remaining women in our cohort all cytologically normal at enrollment These women are being followed passively via linkage to the cytology and tumor registries in Cost Rica
Clinical visits conducted during follow-up consist of a brief personal interview that collects information on exposures since enrollment the collection of 15ml blood and a pelvic examination Pap smear is prepared during the pelvic examination and additional cervical specimens are collected and used to prepare a monolayer smear ThinPrep and for human papillomavirus and other testing Similar to the enrollment visit cervigrams are also collected from each participant at the time of their follow-up visits
During follow-up women with any evidence of progression to HSIL or cancer by Pap smear ThinPrep cervicography or by visual inspection are referred to colposcopy censored from the study and treated by Social Security Administration clinicians using standard local protocols
Women without evidence of HSIL or cancer at enrollment comprise the group of subjects who have been followed as part of our longitudinal study Three distinct groups of women of approximately equal size about 3000 women each exist within our longitudinal cohort The first group consists of women who at enrollment had evidence of low-grade cervical lesions LSIL or equivocal lesions and a sample of the remaining cohort members This group is being followed actively at 6-12 month intervals through their seventh anniversary in the cohort The second group consists of women who were cytologically normal at enrollment but randomly selected for active follow-up This second group will be seen once after enrollment at their fifth anniversary in the cohort Women in this group with evidence of LSIL at the fifth anniversary visit will be added to the first group described above and followed at 6-month intervals The final group consists of the remaining women in our cohort all cytologically normal at enrollment These women are being followed passively via linkage to the cytology and tumor registries in Cost Rica
Clinical visits conducted during follow-up consist of a brief personal interview that collects information on exposures since enrollment the collection of 15ml blood and a pelvic examination Pap smear is prepared during the pelvic examination and additional cervical specimens are collected and used to prepare a monolayer smear ThinPrep and for human papillomavirus and other testing Similar to the enrollment visit cervigrams are also collected from each participant at the time of their follow-up visits
During follow-up women with any evidence of progression to HSIL or cancer by Pap smear ThinPrep cervicography or by visual inspection are referred to colposcopy censored from the study and treated by Social Security Administration clinicians using standard local protocols
Detailed Description:
A population-based study was initiated in Costa Rica in June 1993 to investigate the natural history of human papillomaviruses HPV and cervical neoplasia Over a period of 18 months ending in December 1994 10080 women were recruited into our study after informed consent was obtained At the initial recruitment visit all women were administered a brief risk factor questionnaire had 15ml of blood collected and if sexually active were given a pelvic examination At the time of the pelvic examination a Pap smear was collected as were additional cervical cells which were then used for additional monolayer smears ThinPrep and for human papillomavirus and other testing Pictures of the cervix known as cervigrams were also taken as a third screening test Based on these screening tests women were referred to colposcopy at which time a more detailed risk factor questionnaire was administered additional cervical cells and blood 15ml were collected and histological specimens were obtained if indicated by the colposcopy Women diagnosed with a high-grade cervical lesion HSIL or cervical cancers were treated by Social Security Administration clinicians using standard local protocols
Women without evidence of HSIL or cancer at enrollment comprise the group of subjects who were followed as part of our longitudinal study Three distinct groups of women of approximately equal size about 3000 women each exist within our longitudinal cohort The first group consists of women who at enrollment had evidence of low-grade cervical lesions LSIL or equivocal lesions and a sample of the remaining cohort members This group was followed actively at 6-12 month intervals through their seventh anniversary in the cohort The second group consists of women who were cytologically normal at enrollment but randomly selected for active follow-up This second group was seen once after enrollment close to fifth anniversary in the cohort Women in this group with evidence of LSIL at the fifth anniversary visit were added to the first group described above and followed at 6-month intervals The final group consists of the remaining women in our cohort all cytologically normal at enrollment These women were followed passively via linkage to the cytology and tumor registries in Costa Rica
Clinical visits conducted during follow-up consisted of a brief personal interview that collects information on exposures since enrollment the collection of 15ml blood and a pelvic examination A Pap smear was prepared during the pelvic examination and additional cervical specimens were collected and used to prepare a monolayer smear ThinPrep and for human papillomavirus and other testing Similar to the enrollment visit cervigrams were also collected from each participant at the time of their follow-up visits
During follow-up women with any evidence of progression to HSIL or cancer by Pap smear ThinPrep cervicography or by visual inspection were referred to colposcopy censored from the study and treated by Social Security Administration clinicians using standard local protocols
Women without evidence of HSIL or cancer at enrollment comprise the group of subjects who were followed as part of our longitudinal study Three distinct groups of women of approximately equal size about 3000 women each exist within our longitudinal cohort The first group consists of women who at enrollment had evidence of low-grade cervical lesions LSIL or equivocal lesions and a sample of the remaining cohort members This group was followed actively at 6-12 month intervals through their seventh anniversary in the cohort The second group consists of women who were cytologically normal at enrollment but randomly selected for active follow-up This second group was seen once after enrollment close to fifth anniversary in the cohort Women in this group with evidence of LSIL at the fifth anniversary visit were added to the first group described above and followed at 6-month intervals The final group consists of the remaining women in our cohort all cytologically normal at enrollment These women were followed passively via linkage to the cytology and tumor registries in Costa Rica
Clinical visits conducted during follow-up consisted of a brief personal interview that collects information on exposures since enrollment the collection of 15ml blood and a pelvic examination A Pap smear was prepared during the pelvic examination and additional cervical specimens were collected and used to prepare a monolayer smear ThinPrep and for human papillomavirus and other testing Similar to the enrollment visit cervigrams were also collected from each participant at the time of their follow-up visits
During follow-up women with any evidence of progression to HSIL or cancer by Pap smear ThinPrep cervicography or by visual inspection were referred to colposcopy censored from the study and treated by Social Security Administration clinicians using standard local protocols
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| OH99-C-N030 | None | None | None |