Ignite Creation Date:
2024-05-05 @ 4:54 PM
Last Modification Date:
2024-10-26 @ 9:25 AM
Study NCT ID:
NCT00342407
Status:
COMPLETED
Last Update Posted:
2020-04-10
First Post:
2006-06-19
Brief Title:
The Incidence of Breast and Other Cancers Among Female Flight Attendants
Sponsor:
National Cancer Institute NCI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
The Incidence of Breast and Other Cancers Among Female Flight Attendants
Status:
COMPLETED
Status Verified Date:
2020-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Flight attendants may be at an increased risk of breast and other cancers due to work-place exposures including cosmic radiation and circadian rhythm disruption form traveling across multiple time zones This cancer incidence study will determine whether female flight attendants are at increased risk of breast and other cancers and whether the risk is dose-related The study will include a cohort of approximately 10000 women who were employed as flight attendants for one or more years
Breast cancer cases will be identified from telephone interviews of living subjects and next-of-kin of deceased subjects as well as from death certificates The interview will also provide information about non-occupational risk factors for breast cancer such as parity Both internal and external comparisons will be made The primary analysis will evaluate the risk associated with occupational exposure within the cohort controlling for non-occupational risk factors by stratification or modeling The secondary analysis will compare the incidence of breast cancer in the cohort to that in the general population with adjustment for factors such as lower parity which might increase breast cancer risk in the cohort independent of occupational exposure to cosmic radiation and circadian rhythm disruption The risk of other ionizing radiation-related cancers such as leukemia lung cancer and thyroid cancer among flight attendants will also be evaluated The results of the study will apply to female flight crew and frequent fliers
Breast cancer cases will be identified from telephone interviews of living subjects and next-of-kin of deceased subjects as well as from death certificates The interview will also provide information about non-occupational risk factors for breast cancer such as parity Both internal and external comparisons will be made The primary analysis will evaluate the risk associated with occupational exposure within the cohort controlling for non-occupational risk factors by stratification or modeling The secondary analysis will compare the incidence of breast cancer in the cohort to that in the general population with adjustment for factors such as lower parity which might increase breast cancer risk in the cohort independent of occupational exposure to cosmic radiation and circadian rhythm disruption The risk of other ionizing radiation-related cancers such as leukemia lung cancer and thyroid cancer among flight attendants will also be evaluated The results of the study will apply to female flight crew and frequent fliers
Detailed Description:
Flight attendants may be at an increased risk of breast and other cancers due to work-place exposures including cosmic radiation and circadian rhythm disruption from traveling across multiple time zones This cancer incidence study will determine whether female flight attendants are at increased risk of breast and other cancers and whether the risk is dose-related The study will include a cohort of approximately 9631 women who were employed as flight attendants for one or more years
Breast cancer cases will be identified from telephone interviews of living subjects and next-of-kin of deceased subjects as well as from death certificates The interview will also provide information about non-occupational risk factors for breast cancer such as parity Both internal and external comparisons will be made The primary analysis will evaluate the risk associated with occupational exposure within the cohort controlling for non-occupational risk factors by stratification or modeling The secondary analysis will compare the incidence of breast cancer in the cohort to that in the general population with adjustment for factors such as lower parity which might increase breast cancer risk in the cohort independent of occupational exposure to cosmic radiation and circadian rhythm disruption The risk of other ionizing radiation-related cancers such as leukemia lung cancer and thyroid cancer among flight attendants will also be evaluated The results of the study will apply to female flight crew and frequent fliers
Breast cancer cases will be identified from telephone interviews of living subjects and next-of-kin of deceased subjects as well as from death certificates The interview will also provide information about non-occupational risk factors for breast cancer such as parity Both internal and external comparisons will be made The primary analysis will evaluate the risk associated with occupational exposure within the cohort controlling for non-occupational risk factors by stratification or modeling The secondary analysis will compare the incidence of breast cancer in the cohort to that in the general population with adjustment for factors such as lower parity which might increase breast cancer risk in the cohort independent of occupational exposure to cosmic radiation and circadian rhythm disruption The risk of other ionizing radiation-related cancers such as leukemia lung cancer and thyroid cancer among flight attendants will also be evaluated The results of the study will apply to female flight crew and frequent fliers
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 02-C-N039 | None | None | None |