Ignite Creation Date:
2024-05-05 @ 4:54 PM
Last Modification Date:
2024-10-26 @ 9:25 AM
Study NCT ID:
NCT00345150
Status:
COMPLETED
Last Update Posted:
2006-06-27
First Post:
2006-06-24
Brief Title:
Effects of Inhibition of NO-Synthesis on Renal Hemodynamics and Sodium Excretion in Patients With Essential Hypertension and Healthy Controls
Sponsor:
Regional Hospital Holstebro
Organization:
Regional Hospital Holstebro
Study Overview
Official Title:
Phase 1 Study of the Effects of Systemic Nitric Oxide Inhibition With Ng-Monomethyl-L-Arginine on Renal Hemodynamics and Sodium Excretion in Patients With Essential Hypertension and Healthy Controls
Status:
COMPLETED
Status Verified Date:
2006-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The study tests the hypothesis that systemic and renal nitric oxide synthesis is changed in essential hypertension by investigating the effects of a non selective nitric oxide inhibitor on renal hemodynamics and sodium excretion in patients with essential hypertension The results are compared with a group of healthy subjects
Detailed Description:
The study investigates the effects of Ng-monomethyl-L-arginine L-NMMA on
1 renal hemodynamics renal plasma flow and glomerular filtration rate
2 renal sodium excretion
3 lithium clearance and fractional lithium excretion
4 plasma levels of vasoactive hormones
5 blood pressure and heart rate
1 renal hemodynamics renal plasma flow and glomerular filtration rate
2 renal sodium excretion
3 lithium clearance and fractional lithium excretion
4 plasma levels of vasoactive hormones
5 blood pressure and heart rate
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None