Ignite Creation Date:
2024-05-06 @ 12:56 PM
Last Modification Date:
2024-10-26 @ 1:06 PM
Study NCT ID:
NCT03896373
Status:
COMPLETED
Last Update Posted:
2021-02-24
First Post:
2019-03-27
Brief Title:
Role of the Neonatal Fc Receptor for IgG in the Pathophysiology of Lupus
Sponsor:
University Hospital Tours
Organization:
University Hospital Tours
Study Overview
Official Title:
Role of the Neonatal Fc Receptor for IgG in the Pathophysiology of Lupus
Status:
COMPLETED
Status Verified Date:
2021-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
RFPL
Brief Summary:
This study evaluates the expression of the neonatal fc receptor FcRn in white blood cells and antigen-presenting cells APC in active lupus patients compared to inactive lupus patients and control to investigate if its upregulated or not
Detailed Description:
FcRn is an intracellular receptor which binds the Fc of immunoglobulins G IgG and albumin which induce an upgraded half-life of this two proteins
Its extended role involve the regulation of immune complexes and anti-tumoral immunity some studies showing a direct correlation between its expression and the tumor surface and prognosis
Recently a role in the upregulation of humoral response with a increase of the antibodiess diversity and a more efficient priming of lymphocyte B have been evocated
The lupus erythematosus is an auto-immune disease mediated by IgG and immune complexes characterized by a high diversity of autoantibodies and a large dysregulation of the immune system in all its components
In this study by analogy with the founding in anti-tumoral immunity the investigators hypothesised that in an active lupus disease the expression of FcRn is upregulated in the white blood cells and in APC
This is followed by an extended half life of IgG autoantibodies and immune complexes inducing direct damages by their deposit in tissues and indirectly by upregulating the humoral response leading to anormal production of a large panel of autoantibodies
Its extended role involve the regulation of immune complexes and anti-tumoral immunity some studies showing a direct correlation between its expression and the tumor surface and prognosis
Recently a role in the upregulation of humoral response with a increase of the antibodiess diversity and a more efficient priming of lymphocyte B have been evocated
The lupus erythematosus is an auto-immune disease mediated by IgG and immune complexes characterized by a high diversity of autoantibodies and a large dysregulation of the immune system in all its components
In this study by analogy with the founding in anti-tumoral immunity the investigators hypothesised that in an active lupus disease the expression of FcRn is upregulated in the white blood cells and in APC
This is followed by an extended half life of IgG autoantibodies and immune complexes inducing direct damages by their deposit in tissues and indirectly by upregulating the humoral response leading to anormal production of a large panel of autoantibodies
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 2019-A00394-53 | OTHER | IdRCB | None |