Ignite Creation Date:
2024-05-05 @ 4:54 PM
Last Modification Date:
2024-10-26 @ 9:25 AM
Study NCT ID:
NCT00342641
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
2006-06-19
Brief Title:
Association Between Hepatitis C Virus Infection and Hematologic and Thyroid Cancers
Sponsor:
National Cancer Institute NCI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Associations of Hematologic Malignancies and Thyroid Cancer With HCV Infection Among US Military Veterans
Status:
COMPLETED
Status Verified Date:
2011-12-13
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will investigate the possible relationship between infection with hepatitis C virus HCV and the development of certain hematologic cancers Non-Hodgkins lymphoma Hodgkins lymphoma chronic lymphocytic leukemia multiple myeloma and thyroid cancer HCV causes chronic hepatitis cirrhosis and liver cancer It is transmitted primarily through injection drug use and transfusion of infected blood Studies have shown that HCV may also be linked to hematologic cancers and thyroid cancer
This retrospective study will examine medical records from veterans with and without HCV infection who previously received treatment in the Veterans Administration medical system Data collected on each subject will include the subjects race sex age and era of military service presence of liver disease or thyroiditis at their baseline clinic visit number of inpatient visits in the past 5 years and outpatient visits in the past year and the presence of various specified cancers The prevalence of cancer and other conditions among HCV-infected subjects and non-HCV infected subjects at baseline and the subsequent development of the cancers of interest in these two groups will be compared and analyzed for a possible causal relationship
This retrospective study will examine medical records from veterans with and without HCV infection who previously received treatment in the Veterans Administration medical system Data collected on each subject will include the subjects race sex age and era of military service presence of liver disease or thyroiditis at their baseline clinic visit number of inpatient visits in the past 5 years and outpatient visits in the past year and the presence of various specified cancers The prevalence of cancer and other conditions among HCV-infected subjects and non-HCV infected subjects at baseline and the subsequent development of the cancers of interest in these two groups will be compared and analyzed for a possible causal relationship
Detailed Description:
Hepatitis C virus HCV may be a cause of hematologic malignancies and thyroid cancer HCV infection is common among US military veterans receiving care in the Veterans Administration healthcare system The investigators propose a retrospective cohort study using VA administrative databases A cohort of approximately 147000 HCV-infected veterans has been identified for the period 1997-2004 Likewise a cohort of approximately 573000 HCV-uninfected veterans has been identified for the same period These subjects are being evaluated for the diagnosis of hematologic malignancies thyroid cancer and related medical conditions as recorded in VA databases The comparison of the prevalence and incidence of these cancers in the two cohorts will provide a test of the hypothesis that HCV infection can cause these cancers
The investigators will also evaluate the association between HCV infection and several other medical conditions which might be related to HCV infection specifically immune thrombocytopenic purpura autoimmune hemolytic anemia cholangiocarcinoma cholangitis and pancreatic cancer
The investigators will also evaluate the association between HCV infection and several other medical conditions which might be related to HCV infection specifically immune thrombocytopenic purpura autoimmune hemolytic anemia cholangiocarcinoma cholangitis and pancreatic cancer
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 05-C-N172 | None | None | None |