Ignite Creation Date:
2024-05-06 @ 12:55 PM
Last Modification Date:
2024-10-26 @ 1:06 PM
Study NCT ID:
NCT03888040
Status:
RECRUITING
Last Update Posted:
2024-03-27
First Post:
2019-03-14
Brief Title:
Fatigability of Lower Limb Muscle in Older Adults Protective Effects of Strength Training Exercise in Old Men and Women
Sponsor:
Marquette University
Organization:
Marquette University
Study Overview
Official Title:
Fatigability of Limb Muscle in Older Adults Protective Effects of Exercise
Status:
RECRUITING
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The proposed studies will assess 1 the mechanisms for the age-related increase in fatigability during dynamic exercise Aims 1 and 2 and 2 the effectiveness of high-velocity resistance training coupled with blood flow restriction BFR in improving muscle power output and fatigability in older adults Aim 3 The first two aims are cross-sectional studies comparing young 18-35 years old and older adults 60 yrs old to test our central hypothesis that the greater accumulation of metabolites and increase in fatigability in older adults is due to either age-related impairments in skeletal muscle bioenergetics Aim 1 andor vascular dysfunction Aim 2 These two aims will integrate techniques to assess whole-muscle bioenergetics 31P-MRS and in vivo vascular function near infrared spectroscopy NIRS and doppler ultrasonography with in vitro assessment of single fiber bioenergetics epifluorescence microscopy and vasoreactivity of isolated skeletal muscle arterioles video microscopy We will then determine whether bioenergetics vascular function and fatigability are altered in older men and women in response to 8 weeks of resistance exercise training of the lower limb both with and without blood flow restriction Aim 3
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01AG048262 | NIH | None | httpsreporternihgovquickSearchR01AG048262 |