Ignite Creation Date:
2024-05-05 @ 4:54 PM
Last Modification Date:
2024-10-26 @ 9:25 AM
Study NCT ID:
NCT00344916
Status:
COMPLETED
Last Update Posted:
2006-07-11
First Post:
2006-06-24
Brief Title:
Phase 1 Study of L-NMMA in Patients With Liver Cirrhosis
Sponsor:
Regional Hospital Holstebro
Organization:
Regional Hospital Holstebro
Study Overview
Official Title:
NO-Synthesis in Patients With Liver Cirrhosis Effect of L-NMMA on Renal Hemodynamics Sodium Excretion and Plasma Levels of Vasoactive Hormones
Status:
COMPLETED
Status Verified Date:
2006-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Phase 1 study of the effects of nitric oxide inhibition with L-NMMA in patients with liver cirrhosis and healthy controls It is hypothesized that nitric oxide availability is increased in liver cirrhosis
Detailed Description:
In a randomized placebo controlled design the acute effects of Ng-monomethyl-L-arginine are studied on
renal hemodynamics GFR and RPF
blood pressure and heart rate
lithium clearance
plasma levels of vasoactive hormones
renal hemodynamics GFR and RPF
blood pressure and heart rate
lithium clearance
plasma levels of vasoactive hormones
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None